Dr Francis Galaway | Postdoctoral Fellow

Galaway, Francis

Francis is a staff scientist in the Cell Surface Signalling Laboratory at the Sanger Institute. His work covers the invasion of human red blood cells by the parasite Plasmodium falciparum with a focus on understanding protein interactions in order to develop better vaccines for malaria.

My current work uses biochemical techniques to study the molecular details of the protein RH5 and its interactions with other P. falciparum proteins during invasion of erythrocytes. RH5 is an exciting prospect for vaccines against malaria so I have also been exploring antigen designs that will produce invasion blocking antibodies.

Previously, at the University of Leeds, I developed a self-assembling protein cage for delivering siRNA into mammalian cells. This nanoparticle was based on the bacteriophage MS2. A major part of the work was trialing ligands that allow cancerous tissues to be targeted and so I became interested in the protein interactions at cell surfaces that allow a nanoparticle or pathogen to enter.


  • P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5.

    Galaway F, Drought LG, Fala M, Cross N, Kemp AC et al.

    Nature communications 2017;8;14333

  • Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

    Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR et al.

    Cell 2019;178;1;216-228.e21

  • Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions.

    Payne RO, Silk SE, Elias SC, Miura K, Diouf A et al.

    JCI insight 2017;2;21

  • MS2 viruslike particles: a robust, semisynthetic targeted drug delivery platform.

    Galaway FA and Stockley PG

    Molecular pharmaceutics 2013;10;1;59-68

  • Comparative Antibody Responses Against three Antimalarial Vaccine Candidate Antigens from Urban and Rural Exposed Individuals in Gabon.

    Imboumy-Limoukou RK, Oyegue-Liabagui SL, Ndidi S, Pegha-Moukandja I, Kouna CL et al.

    European journal of microbiology & immunology 2016;6;4;287-297

Galaway, Francis
Francis's Timeline

Staff Scientist at Wellcome Trust Sanger Institute


Became a PostDoc at the Wellcome Trust Sanger Institute


PhD in Structural and Cell Biology, University of Leeds


BSc in Biology, University of York


Colchester Grammar School