Dr Avril Coghlan | Senior Bioinformatician

Coghlan, Avril

I am a bioinformatician working on parasitic worm genomes. I am interested in understanding how the genomes of parasitic worms (nematodes and platyhelminths) evolve; in identifying worm drug targets and predicting potential novel anthelmintic drugs; and in helping lab biologists to develop new tools to study the biology of parasitic worms.

I am also interested in statistics and bioinformatics methodology, and I've written The Little Books of R (http://little-books-of-r.readthedocs.io/en/latest/) and write a blog on things I learn about bioinformatics, called avrilomics (http://avrilomics.blogspot.co.uk/).

Publications

  • The genomic basis of parasitism in the Strongyloides clade of nematodes.

    Hunt VL, Tsai IJ, Coghlan A, Reid AJ, Holroyd N et al.

    Nature genetics 2016;48;3;299-307

  • The genome of the sparganosis tapeworm Spirometra erinaceieuropaei isolated from the biopsy of a migrating brain lesion.

    Bennett HM, Mok HP, Gkrania-Klotsas E, Tsai IJ, Stanley EJ et al.

    Genome biology 2014;15;11;510

  • Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses.

    Woods S, Coghlan A, Rivers D, Warnecke T, Jeffries SJ et al.

    PLoS genetics 2013;9;5;e1003330

  • The genome of the blood fluke Schistosoma mansoni.

    Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP et al.

    Nature 2009;460;7253;352-8

  • TreeFam: a curated database of phylogenetic trees of animal gene families.

    Li H, Coghlan A, Ruan J, Coin LJ, Hériché JK et al.

    Nucleic acids research 2006;34;Database issue;D572-80

  • The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.

    Stein LD, Bao Z, Blasiar D, Blumenthal T, Brent MR et al.

    PLoS biology 2003;1;2;E45

  • Origins of recently gained introns in Caenorhabditis.

    Coghlan A and Wolfe KH

    Proceedings of the National Academy of Sciences of the United States of America 2004;101;31;11362-7

  • Fourfold faster rate of genome rearrangement in nematodes than in Drosophila.

    Coghlan A and Wolfe KH

    Genome research 2002;12;6;857-67

  • Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae.

    Coghlan A and Wolfe KH

    Yeast (Chichester, England) 2000;16;12;1131-45

  • Genomix: a method for combining gene-finders' predictions, which uses evolutionary conservation of sequence and intron-exon structure.

    Coghlan A and Durbin R

    Bioinformatics (Oxford, England) 2007;23;12;1468-75

Coghlan, Avril
Avril's Timeline
2017

BSc Mathematics & Statistics, Open University, UK

2012

Joined the Parasite Genomics (Matthew Berriman) group, Wellcome Sanger Institute

2008

Lecturer in Bioinformatics, University College Cork, Ireland

2005

Postdoctoral fellow, Richard Durbin group, Wellcome Sanger Institute

2003

PhD, Ken Wolfe group, Trinity College Dublin, Ireland

1999

BA Genetics, Trinity College Dublin, Ireland