William is a Senior Bioinformatician at the Wellcome Sanger Institute providing analyses and informatics support for the Genome Reference Informatics team (GRIT).
GRIT forms the Sanger Institute division for the Genome Reference Consortium who are tasked with ensuring the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation. The team has now extended similar efforts to the international Vertebrate Genomes Project/Earth Biogenome Project, an ambitious project to produce an error-free, near gapless, chromosomal level, haplotyped phase assembly for all ~66,000 vertebrate species on earth.
William is the lead developer of the gEVAL browser, a web based genome browser for evaluating and curating genome assemblies.
He is also currently involved with the UK based Darwin Tree of Life Project, a Wellcome Sanger Institute leading UK-wide initiative to read the genomes of all 60,000 complex species (eukaryotes) in the British Isles.
Besides the GRC and genomes, he has also assisted in the development of reference genomes for many species including but not limiting, pig, chicken, various helminth worms and in a previous position the salmon (salmo salar) genome.
Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome.
Genome biology 2019;20;1;207
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.
Nature genetics 2018;50;11;1574-1583
Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.
Genome research 2018;28;4;448-459
Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.
Genome research 2017;27;5;849-864
A New Chicken Genome Assembly Provides Insight into Avian Genome Structure.
G3 (Bethesda, Md.) 2017;7;1;109-117
gEVAL - a web-based browser for evaluating genome assemblies.
Bioinformatics (Oxford, England) 2016;32;16;2508-10
The pig X and Y Chromosomes: structure, sequence, and evolution.
Genome research 2016;26;1;130-9
Third Report on Chicken Genes and Chromosomes 2015.
Cytogenetic and genome research 2015;145;2;78-179
The zebrafish reference genome sequence and its relationship to the human genome.
Analyses of pig genomes provide insight into porcine demography and evolution.
Modernizing reference genome assemblies.
PLoS biology 2011;9;7;e1001091
Genomic organization and evolution of the Atlantic salmon hemoglobin repertoire.
BMC genomics 2010;11;539
Genomic organization of Atlantic salmon (Salmo salar) fatty acid binding protein (fabp2) genes reveals independent loss of duplicate loci in teleosts.
Marine genomics 2009;2;3-4;193-200
Genomic organization and evolution of the vomeronasal type 2 receptor-like (OlfC) gene clusters in Atlantic salmon, Salmo salar.
Molecular biology and evolution 2009;26;5;1117-25
Assessing the feasibility of GS FLX Pyrosequencing for sequencing the Atlantic salmon genome.
BMC genomics 2008;9;404
Genomic organization and characterization of two vomeronasal 1 receptor-like genes (ora1 and ora2) in Atlantic salmon Salmo salar.
Marine genomics 2008;1;1;23-31
Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling.
Genome research 2006;16;6;796-803