William Chow, MRSB | Senior Bioinformatician

Chow, William

William is a Senior Bioinformatician at the Wellcome Sanger Institute providing analyses and informatics support for the Genome Reference Informatics team (GRIT).

GRIT forms the Sanger Institute division for the Genome Reference Consortium who are tasked with ensuring the human, mouse and zebrafish reference assemblies are biologically relevant by closing gaps, fixing errors and representing complex variation.  The team has now extended similar efforts to the international Vertebrate Genomes Project/Earth Biogenome Project, an ambitious project to produce an error-free, near gapless, chromosomal level, haplotyped phase assembly for all ~66,000 vertebrate species on earth.

William is the lead developer of the gEVAL browser, a web based genome browser for evaluating and curating genome assemblies.

He is also currently involved with the UK based Darwin Tree of Life Project, a Wellcome Sanger Institute leading UK-wide initiative to read the genomes of all 60,000 complex species (eukaryotes) in the British Isles.

Besides the GRC and genomes, he has also assisted in the development of reference genomes for many species including but not limiting, pig, chicken, various helminth worms and in a previous position the salmon (salmo salar) genome.

Publications

  • Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome.

    Shi W, Massaia A, Louzada S, Handsaker J, Chow W et al.

    Genome biology 2019;20;1;207

  • Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.

    Lilue J, Doran AG, Fiddes IT, Abrudan M, Armstrong J et al.

    Nature genetics 2018;50;11;1574-1583

  • Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.

    Thybert D, Roller M, Navarro FCP, Fiddes I, Streeter I et al.

    Genome research 2018;28;4;448-459

  • Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly.

    Schneider VA, Graves-Lindsay T, Howe K, Bouk N, Chen HC et al.

    Genome research 2017;27;5;849-864

  • A New Chicken Genome Assembly Provides Insight into Avian Genome Structure.

    Warren WC, Hillier LW, Tomlinson C, Minx P, Kremitzki M et al.

    G3 (Bethesda, Md.) 2017;7;1;109-117

  • gEVAL - a web-based browser for evaluating genome assemblies.

    Chow W, Brugger K, Caccamo M, Sealy I, Torrance J and Howe K

    Bioinformatics (Oxford, England) 2016;32;16;2508-10

  • The pig X and Y Chromosomes: structure, sequence, and evolution.

    Skinner BM, Sargent CA, Churcher C, Hunt T, Herrero J et al.

    Genome research 2016;26;1;130-9

  • Third Report on Chicken Genes and Chromosomes 2015.

    Schmid M, Smith J, Burt DW, Aken BL, Antin PB et al.

    Cytogenetic and genome research 2015;145;2;78-179

  • The zebrafish reference genome sequence and its relationship to the human genome.

    Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C et al.

    Nature 2013;496;7446;498-503

  • Analyses of pig genomes provide insight into porcine demography and evolution.

    Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y et al.

    Nature 2012;491;7424;393-8

  • Genomic organization and evolution of the Atlantic salmon hemoglobin repertoire.

    Quinn NL, Boroevich KA, Lubieniecki KP, Chow W, Davidson EA et al.

    BMC genomics 2010;11;539

  • Genomic organization of Atlantic salmon (Salmo salar) fatty acid binding protein (fabp2) genes reveals independent loss of duplicate loci in teleosts.

    Lai YY, Lubieniecki KP, Phillips RB, Chow W, Koop BF and Davidson WS

    Marine genomics 2009;2;3-4;193-200

  • Genomic organization and evolution of the vomeronasal type 2 receptor-like (OlfC) gene clusters in Atlantic salmon, Salmo salar.

    Johnstone KA, Ciborowski KL, Lubieniecki KP, Chow W, Phillips RB et al.

    Molecular biology and evolution 2009;26;5;1117-25

  • Assessing the feasibility of GS FLX Pyrosequencing for sequencing the Atlantic salmon genome.

    Quinn NL, Levenkova N, Chow W, Bouffard P, Boroevich KA et al.

    BMC genomics 2008;9;404

  • Genomic organization and characterization of two vomeronasal 1 receptor-like genes (ora1 and ora2) in Atlantic salmon Salmo salar.

    Johnstone KA, Lubieniecki KP, Chow W, Phillips RB, Koop BF and Davidson WS

    Marine genomics 2008;1;1;23-31

  • Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling.

    Morin RD, Chang E, Petrescu A, Liao N, Griffith M et al.

    Genome research 2006;16;6;796-803

Chow, William
William's Timeline
2008

Joined Wellcome Trust Sanger Institute

2005

Bioinformatician - Consortium for Genomic Research on All Salmonids

2004

Computational Biologist - Michael Smith Genome Sciences Centre

2003

Data Analyst - ActivePass Pharmaceuticals