Bradley, Allan
Allan served as the Institute’s Director from 2000 to 2010. During his ten-year tenure he shifted the Institute’s scientific programmes from a sequence production and informatics to a more genetically and biologically focused academic genome centre. He emphasised investment in young scientists, recruiting a cadre of young PIs, established international PhD programs for both basic and clinically trained candidates.
Professor Bradley led a research group through his tenure as Institute Director and continues to do so as a Senior Group Leader. Allan’s laboratory environment emphasises intellectual rigour but with a flair for innovation and creativity. His laboratory’s research is strongly focused on using genetics to discover genes involved in various biological systems, using somatic mutagenesis in mice to discover cancer genes and genetic screens in ES cells in culture. He is considers himself to be an “educator”, inspiring and mentoring graduate students and fellows. His laboratory is an active and successful training environment for postdoctoral and clinical fellows. Professor Bradley places special emphasis in mentoring and preparing young scientists for independent academic positions both in the UK and globally. Laboratory alumni include 22 independent PIs in 6 countries of whom 10 are full professors, or equivalent.
Allan is also a serial entrepreneur, establishing several biotechnology companies. While in the USA he founded two companies; Lexicon Pharmaceuticals Inc. is publicly traded while Spectral Genomics Inc. was acquired. In 2010 he founded Kymab Ltd., which now employs more than 80 scientists. Many of Prof. Bradley’s trainees have joined these spin-outs.
Publications
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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines.
Nature 1984;309;5965;255-6
PUBMED: 6717601; DOI: 10.1038/309255a0
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A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.
Nature 1987;326;6110;295-8
PUBMED: 3029599; DOI: 10.1038/326295a0
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
Nature 1992;356;6366;215-21
PUBMED: 1552940; DOI: 10.1038/356215a0
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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.
Nature 1992;359;6393;288-94
PUBMED: 1406932; DOI: 10.1038/359288a0
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Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.
Nature 1992;360;6402;313-9
PUBMED: 1448148; DOI: 10.1038/360313a0
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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Nature 1997;386;6627;804-10
PUBMED: 9126738; DOI: 10.1038/386804a0
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p63 is a p53 homologue required for limb and epidermal morphogenesis.
Nature 1999;398;6729;708-13
PUBMED: 10227293; DOI: 10.1038/19531
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Engineering a mouse balancer chromosome.
Nature genetics 1999;22;4;375-8
PUBMED: 10431243; DOI: 10.1038/11949
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Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
Nature genetics 2000;26;4;424-9
PUBMED: 11101838; DOI: 10.1038/82548
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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.
Nature 2004;429;6994;891-5
PUBMED: 15215866; DOI: 10.1038/nature02653
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Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316;5824;608-11
PUBMED: 17463290; PMC: 2610435; DOI: 10.1126/science.1139253
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Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.
Cell 2009;137;7;1235-46
PUBMED: 19563756; PMC: 3710970; DOI: 10.1016/j.cell.2009.04.024
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A conditional knockout resource for the genome-wide study of mouse gene function.
Nature 2011;474;7351;337-42
PUBMED: 21677750; PMC: 3572410; DOI: 10.1038/nature10163
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A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
Nature biotechnology 2011;29;9;840-5
PUBMED: 21822254; PMC: 3242032; DOI: 10.1038/nbt.1929
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Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
Cell 2013;154;2;452-64
PUBMED: 23870131; PMC: 3717207; DOI: 10.1016/j.cell.2013.06.022
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Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
Nature biotechnology 2014;32;4;356-63
PUBMED: 24633243; DOI: 10.1038/nbt.2825
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A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.
mBio 2019;10;5
PUBMED: 31594818; DOI: 10.1128/mBio.02169-19
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NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia.
Blood 2019;134;4;383-388
PUBMED: 31186273; DOI: 10.1182/blood.2018883140; URL:
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Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.
Stem cell reports 2019;12;4;757-771
PUBMED: 30905739; PMC: 6450436; DOI: 10.1016/j.stemcr.2019.02.010
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PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.
Nature communications 2019;10;1;1415
PUBMED: 30926791; PMC: 6440946; DOI: 10.1038/s41467-019-09180-3
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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Nature communications 2019;10;1;87
PUBMED: 30622252; PMC: 6325118; DOI: 10.1038/s41467-018-07729-2
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PiggyBac Transposon-Based Insertional Mutagenesis in Mice.
Methods in molecular biology (Clifton, N.J.) 2019;1907;171-183
PUBMED: 30543000; DOI: 10.1007/978-1-4939-8967-6_14
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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nature communications 2018;9;1;5378
PUBMED: 30568163; PMC: 6300607; DOI: 10.1038/s41467-018-07620-0
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Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology 2018;36;8;765-771
PUBMED: 30010673; PMC: 6390938; DOI: 10.1038/nbt.4192
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Inter-homologue repair in fertilized human eggs?
Nature 2018;560;7717;E5-E7
PUBMED: 30089924; DOI: 10.1038/s41586-018-0379-5
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Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.
Immunogenetics 2018;70;4;223-236
PUBMED: 28924718; PMC: 5871656; DOI: 10.1007/s00251-017-1028-0
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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Nature 2018;554;7690;62-68
PUBMED: 29364867; PMC: 6097607; DOI: 10.1038/nature25459
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Revealing hidden complexities of genomic rearrangements generated with Cas9.
Scientific reports 2017;7;1;12867
PUBMED: 28993641; PMC: 5634419; DOI: 10.1038/s41598-017-12740-6
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Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Nature genetics 2017;49;8;1231-1238
PUBMED: 28650483; PMC: 5546242; DOI: 10.1038/ng.3901
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Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.
Scientific reports 2017;7;1;2244
PUBMED: 28533524; PMC: 5440395; DOI: 10.1038/s41598-017-01766-5
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A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
Nature genetics 2017;49;5;730-741
PUBMED: 28319090; PMC: 5409503; DOI: 10.1038/ng.3817
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Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
eLife 2017;6
PUBMED: 28318489; DOI: 10.7554/eLife.20873
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Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.
Nature protocols 2017;12;2;289-309
PUBMED: 28079877; DOI: 10.1038/nprot.2016.164
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Disentangling PTEN-cooperating tumor suppressor gene networks in cancer.
Molecular & cellular oncology 2017;4;4;e1325550
PUBMED: 28868343; PMC: 5540202; DOI: 10.1080/23723556.2017.1325550
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High-throughput discovery of novel developmental phenotypes.
Nature 2016;537;7621;508-514
PUBMED: 27626380; PMC: 5295821; DOI: 10.1038/nature19356
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Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.
Science (New York, N.Y.) 2016
PUBMED: 27608668; DOI: 10.1126/science.aah3945
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C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Nature immunology 2016;17;9;1046-56
PUBMED: 27478939; PMC: 6581540; DOI: 10.1038/ni.3532
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Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.
The EMBO journal 2016
PUBMED: 27558554; DOI: 10.15252/embj.201593103
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Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.
Genome biology 2016;17;1;115
PUBMED: 27246460; PMC: 4888588; DOI: 10.1186/s13059-016-0971-7
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Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.
PLoS genetics 2016;12;4;e1005932
PUBMED: 27054363; PMC: 4824386; DOI: 10.1371/journal.pgen.1005932
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Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
Nature communications 2016;7;10770
PUBMED: 26916719; PMC: 4773438; DOI: 10.1038/ncomms10770
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Chromosome engineering in zygotes with CRISPR/Cas9.
Genesis (New York, N.Y. : 2000) 2016;54;2;78-85
PUBMED: 26742453; PMC: 4819711; DOI: 10.1002/dvg.22915
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Genome wide conditional mouse knockout resources
Drug Discovery Today: Disease Models 2016;20;3;12
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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13982-7
PUBMED: 26508638; PMC: 4653208; DOI: 10.1073/pnas.1512392112
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High-density P300 enhancers control cell state transitions.
BMC genomics 2015;16;903
PUBMED: 26546038; PMC: 4636788; DOI: 10.1186/s12864-015-1905-6
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A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Cell 2015;162;1;146-59
PUBMED: 26140595; DOI: 10.1016/j.cell.2015.05.053
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Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.
Genesis (New York, N.Y. : 2000) 2015;53;2;225-36
PUBMED: 25378133; DOI: 10.1002/dvg.22835
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A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.
Nature genetics 2015;47;1;47-56
PUBMED: 25485836; DOI: 10.1038/ng.3164
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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
Nature medicine 2014;20;11;1340-1347
PUBMED: 25326799; PMC: 4270133; DOI: 10.1038/nm.3646
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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
PLoS genetics 2014;10;10;e1004705
PUBMED: 25340873; PMC: 4207618; DOI: 10.1371/journal.pgen.1004705
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Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;37;13427-32
PUBMED: 25197064; PMC: 4169945; DOI: 10.1073/pnas.1400892111
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Genetic background drives transcriptional variation in human induced pluripotent stem cells.
PLoS genetics 2014;10;6;e1004432
PUBMED: 24901476; PMC: 4046971; DOI: 10.1371/journal.pgen.1004432
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Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
Nature biotechnology 2014;32;4;356-63
PUBMED: 24633243; DOI: 10.1038/nbt.2825
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MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Journal of immunology (Baltimore, Md. : 1950) 2013;191;6;3037-3048
PUBMED: 23960236; PMC: 4162006; DOI: 10.4049/jimmunol.1301289
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A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.
Leukemia 2013;27;9;1917-20
PUBMED: 23478666; PMC: 3768110; DOI: 10.1038/leu.2013.77
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Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture.
Leukemia 2013;27;9;1820-5
PUBMED: 23702683; PMC: 3768109; DOI: 10.1038/leu.2013.117
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Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
Cell 2013;154;2;452-64
PUBMED: 23870131; PMC: 3717207; DOI: 10.1016/j.cell.2013.06.022
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A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
Cancer cell 2013;24;1;15-29
PUBMED: 23845441; PMC: 3706745; DOI: 10.1016/j.ccr.2013.05.014
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Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.
Blood 2013;121;8;1335-44
PUBMED: 23287868; PMC: 3836254; DOI: 10.1182/blood-2012-07-441949
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Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
Nature communications 2013;4;2268
PUBMED: 23917225; PMC: 3758871; DOI: 10.1038/ncomms3268
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Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.
Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;600-10
PUBMED: 22961258; PMC: 3463797; DOI: 10.1007/s00335-012-9418-y
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Genetic screens using the piggyBac transposon.
Methods (San Diego, Calif.) 2011;53;4;366-71
PUBMED: 21185377; PMC: 3650578; DOI: 10.1016/j.ymeth.2010.12.022
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A hyperactive piggyBac transposase for mammalian applications.
Proceedings of the National Academy of Sciences of the United States of America 2011;108;4;1531-6
PUBMED: 21205896; PMC: 3029773; DOI: 10.1073/pnas.1008322108
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PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.
Science (New York, N.Y.) 2010;330;6007;1104-7
PUBMED: 20947725; PMC: 3719098; DOI: 10.1126/science.1193004
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Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.
PloS one 2010;5;4;e9960
PUBMED: 20383322; PMC: 2850915; DOI: 10.1371/journal.pone.0009960
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An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Cell stem cell 2010;6;4;382-95
PUBMED: 20362542; PMC: 2860244; DOI: 10.1016/j.stem.2010.03.004
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The use of DNA transposons for cancer gene discovery in mice.
Methods in enzymology 2010;477;91-106
PUBMED: 20699138; DOI: 10.1016/S0076-6879(10)77006-3
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Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.
PLoS genetics 2009;5;12;e1000759
PUBMED: 20011118; PMC: 2782131; DOI: 10.1371/journal.pgen.1000759
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Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Nature methods 2009;6;7;493-5
PUBMED: 19525957; PMC: 3555078; DOI: 10.1038/nmeth.1342
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Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.
Cell 2009;137;7;1235-46
PUBMED: 19563756; PMC: 3710970; DOI: 10.1016/j.cell.2009.04.024
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Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons.
Genesis (New York, N.Y. : 2000) 2009;47;6;404-8
PUBMED: 19391106; DOI: 10.1002/dvg.20508
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Transposon-mediated genome manipulation in vertebrates.
Nature methods 2009;6;6;415-22
PUBMED: 19478801; PMC: 2867038; DOI: 10.1038/nmeth.1332
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Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.
Nature methods 2009;6;5;363-9
PUBMED: 19337237; PMC: 2677165; DOI: 10.1038/nmeth.1323
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A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells.
Genome research 2009;19;4;667-73
PUBMED: 19233961; PMC: 2665785; DOI: 10.1101/gr.085621.108
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A DNA transposon-based approach to validate oncogenic mutations in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2008;105;50;19904-9
PUBMED: 19064922; PMC: 2597691; DOI: 10.1073/pnas.0807785105
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Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.
Molecular and cellular biology 2008;28;15;4688-96
PUBMED: 18505827; PMC: 2493357; DOI: 10.1128/MCB.00272-08
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Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.
Oncogene 2008;27;32;4503-8
PUBMED: 18391979; PMC: 3706934; DOI: 10.1038/onc.2008.94
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Chromosomal transposition of PiggyBac in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105;27;9290-5
PUBMED: 18579772; PMC: 2440425; DOI: 10.1073/pnas.0801017105
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Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.
Molecular and cellular biology 2008;28;5;1702-12
PUBMED: 18160714; PMC: 2258769; DOI: 10.1128/MCB.01282-07
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microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.
Immunity 2007;27;6;847-59
PUBMED: 18055230; PMC: 4135426; DOI: 10.1016/j.immuni.2007.10.009
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Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316;5824;608-11
PUBMED: 17463290; PMC: 2610435; DOI: 10.1126/science.1139253
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A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells.
Genome biology 2007;8;4;R48
PUBMED: 17407599; PMC: 1895998; DOI: 10.1186/gb-2007-8-4-r48
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A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis.
Genesis (New York, N.Y. : 2000) 2007;45;1;51-8
PUBMED: 17216607; PMC: 2593393; DOI: 10.1002/dvg.20264
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Generation of an inducible and optimized piggyBac transposon system.
Nucleic acids research 2007;35;12;e87
PUBMED: 17576687; PMC: 1919496; DOI: 10.1093/nar/gkm446
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Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.
The American journal of pathology 2006;169;2;515-27
PUBMED: 16877353; PMC: 1698783; DOI: 10.2353/ajpath.2006.050981
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TranscriptSNPView: a genome-wide catalog of mouse coding variation.
Nature genetics 2006;38;8;853
PUBMED: 16874317; PMC: 2610433; DOI: 10.1038/ng0806-853a
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Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.
Genes & development 2006;20;14;1880-4
PUBMED: 16847348; PMC: 1522086; DOI: 10.1101/gad.379706
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A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice.
Genetics 2006;173;1;297-307
PUBMED: 16489219; PMC: 1461454; DOI: 10.1534/genetics.105.054833
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Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.
Molecular and cellular biology 2006;26;9;3595-609
PUBMED: 16611999; PMC: 1447413; DOI: 10.1128/MCB.26.9.3595-3609.2006
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DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature 2006;440;7087;1045-9
PUBMED: 16625196; PMC: 2610434; DOI: 10.1038/nature04689
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A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction.
Genomics 2005;86;6;753-8
PUBMED: 16257172; DOI: 10.1016/j.ygeno.2005.08.003
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The molecular clock mediates leptin-regulated bone formation.
Cell 2005;122;5;803-15
PUBMED: 16143109; DOI: 10.1016/j.cell.2005.06.028
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The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis.
Molecular and cellular biology 2005;25;18;8356-67
PUBMED: 16135822; PMC: 1234312; DOI: 10.1128/MCB.25.18.8356-8367.2005
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Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.
Genesis (New York, N.Y. : 2000) 2005;41;4;171-8
PUBMED: 15789413; DOI: 10.1002/gene.20111
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BRCTx is a novel, highly conserved RAD18-interacting protein.
Molecular and cellular biology 2005;25;2;779-88
PUBMED: 15632077; PMC: 543416; DOI: 10.1128/MCB.25.2.779-788.2005
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Identification of mammalian microRNA host genes and transcription units.
Genome research 2004;14;10A;1902-10
PUBMED: 15364901; PMC: 524413; DOI: 10.1101/gr.2722704
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The knockout mouse project.
Nature genetics 2004;36;9;921-4
PUBMED: 15340423; PMC: 2716027; DOI: 10.1038/ng0904-921
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The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36;9;925-7
PUBMED: 15340424; PMC: 2716028; DOI: 10.1038/ng0904-925
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Mutagenic insertion and chromosome engineering resource (MICER).
Nature genetics 2004;36;8;867-71
PUBMED: 15235602; DOI: 10.1038/ng1388
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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.
Nature 2004;429;6994;891-5
PUBMED: 15215866; DOI: 10.1038/nature02653
-
Functional genetic analysis of mouse chromosome 11.
Nature 2003;425;6953;81-6
PUBMED: 12955145; DOI: 10.1038/nature01865
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Mining the mouse genome.
Nature 2002;420;6915;512-4
PUBMED: 12466846; DOI: 10.1038/420512a
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Tools for targeted manipulation of the mouse genome.
Physiological genomics 2002;11;3;133-64
PUBMED: 12464689; DOI: 10.1152/physiolgenomics.00074.2002
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Cancer: stuck at first base.
Nature 2002;419;6903;127-8
PUBMED: 12226650; DOI: 10.1038/419127a
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p53 mutant mice that display early ageing-associated phenotypes.
Nature 2002;415;6867;45-53
PUBMED: 11780111; DOI: 10.1038/415045a
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Induced mitotic recombination: a switch in time.
Nature genetics 2002;30;1;6-7
PUBMED: 11753379; DOI: 10.1038/ng0102-6
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Engineering chromosomal rearrangements in mice.
Nature reviews. Genetics 2001;2;10;780-90
PUBMED: 11584294; DOI: 10.1038/35093564
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An SSLP marker-anchored BAC framework map of the mouse genome.
Nature genetics 2001;29;2;133-4
PUBMED: 11586294; DOI: 10.1038/ng1001-133
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Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice.
Nature genetics 2001;29;1;78-82
PUBMED: 11528397; DOI: 10.1038/ng715
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Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.
Nature 2001;410;6824;97-101
PUBMED: 11242049; DOI: 10.1038/35065105
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Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
Nature genetics 2000;26;4;424-9
PUBMED: 11101838; DOI: 10.1038/82548
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Requirement for Wnt3 in vertebrate axis formation.
Nature genetics 1999;22;4;361-5
PUBMED: 10431240; DOI: 10.1038/11932