Mr Shriram G Bhosle, M.Sc(Genetics), MBCS | Principal Software Developer

Bhosle, Shriram

My work at Sanger mostly involved development of cancer genomic data analysis pipelines and algorithms. Currently I am working on genomic analysis of cancer Organoids to understand and complemet a bigger picture of underlying biological processes in cancer.

Publications

  • α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

    Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J et al.

    Circulation. Cardiovascular genetics 2014;7;6;920-9

  • Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases.

    Roberts AL, Thomas ER, Bhosle S, Game L, Obraztsova O et al.

    Arthritis research & therapy 2014;16;3;R114

  • Curation of viral genomes: challenges, applications and the way forward.

    Kulkarni-Kale U, Bhosle SG, Manjari GS, Joshi M, Bansode S and Kolaskar AS

    BMC bioinformatics 2006;7 Suppl 5;S12

  • CEP: a conformational epitope prediction server.

    Kulkarni-Kale U, Bhosle S and Kolaskar AS

    Nucleic acids research 2005;33;Web Server issue;W168-71

  • VirGen: a comprehensive viral genome resource.

    Kulkarni-Kale U, Bhosle S, Manjari GS and Kolaskar AS

    Nucleic acids research 2004;32;Database issue;D289-92

  • Characterization of antibody-binding sites on proteins: development of a knowledgebase and its applications in improving epitope prediction.

    Ghate AD, Bhagwat BU, Bhosle SG, Gadepalli SM and Kulkarni-Kale UD

    Protein and peptide letters 2007;14;6;531-5

  • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

    Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC et al.

    Cell 2019;176;6;1282-1294.e20

  • Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma.

    Maura F, Agnelli L, Leongamornlert D, Bolli N, Chan WC et al.

    American journal of hematology 2019;94;6;628-634

  • Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

    Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E et al.

    BMC genomics 2018;19;1;604

  • Genomic Evolution of Breast Cancer Metastasis and Relapse.

    Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S et al.

    Cancer cell 2017;32;2;169-184.e7

  • Pan-cancer analysis of whole genomes.

    ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

    Nature 2020;578;7793;82-93

  • Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma.

    Maura F, Agnelli L, Leongamornlert D, Bolli N, Chan WC et al.

    American journal of hematology 2019;94;6;628-634

  • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

    Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC et al.

    Cell 2019;176;6;1282-1294.e20

  • Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

    Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E et al.

    BMC genomics 2018;19;1;604

  • Genomic Evolution of Breast Cancer Metastasis and Relapse.

    Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S et al.

    Cancer cell 2017;32;2;169-184.e7

  • α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

    Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J et al.

    Circulation. Cardiovascular genetics 2014;7;6;920-9

  • Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases.

    Roberts AL, Thomas ER, Bhosle S, Game L, Obraztsova O et al.

    Arthritis research & therapy 2014;16;3;R114

  • Characterization of antibody-binding sites on proteins: development of a knowledgebase and its applications in improving epitope prediction.

    Ghate AD, Bhagwat BU, Bhosle SG, Gadepalli SM and Kulkarni-Kale UD

    Protein and peptide letters 2007;14;6;531-5

  • Curation of viral genomes: challenges, applications and the way forward.

    Kulkarni-Kale U, Bhosle SG, Manjari GS, Joshi M, Bansode S and Kolaskar AS

    BMC bioinformatics 2006;7 Suppl 5;S12

  • CEP: a conformational epitope prediction server.

    Kulkarni-Kale U, Bhosle S and Kolaskar AS

    Nucleic acids research 2005;33;Web Server issue;W168-71

  • VirGen: a comprehensive viral genome resource.

    Kulkarni-Kale U, Bhosle S, Manjari GS and Kolaskar AS

    Nucleic acids research 2004;32;Database issue;D289-92

Bhosle, Shriram
Shriram's Timeline
2014

Senior Bioinformatician, CGP, Wellcome Trust, Sanger Institute

2012

Bioinformatician, Roslin Institute, University of Edinburgh

2010

Bioinformatician, Imperial college London

2004

Module Lead Bioinformatics, Persistent Systems Ltd.,

2002

Research Associate, Pune University

Advanced Diploma in Bioinformatics

2000

MSc(Genetics)

1998

BSc(Agriculture)