Dr Paul Bevan, MBCS | Core Software Team Leader

Bevan, Paul

My remit is to provide core Software service in terms of operational and project support to the Wellcome Sanger Institute, Wellcome Genome Campus and External scientific partners.

I head Core Software Services which encompasses: the Core Sanger Web Team; Core Bioinformatics (CoreBio); SoftWare Action Team (SWAT) and the Decipher Web Team at the Sanger Institute. I am involved mainly in the day to day service provision and maintenance of the 50 plus public domains at the Sanger Institute including www.sanger.ac.uk. The team also support the internal web infrastructure for the Sanger Institute and Wellcome Genome Campus.

Prior to this I was a research scientist working in the Departments of Medical Genetics and Clinical Biochemistry at the University of Cambridge where I had two major research interests Receptor Tyrosine Kinase Signal Transduction and Autosomal Dominant Polycystic Kidney Disease.

During my time at Cambridge I was webmaster for both of these departments as well as webmaster of the Cambridge Institute for Medical Research website.

Publications

  • Prevalence and architecture of de novo mutations in developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2017;542;7642;433-438

  • Facilitating collaboration in rare genetic disorders through effective matchmaking in DECIPHER.

    Chatzimichali EA, Brent S, Hutton B, Perrett D, Wright CF et al.

    Human mutation 2015;36;10;941-9

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • DECIPHER: database for the interpretation of phenotype-linked plausibly pathogenic sequence and copy-number variation.

    Bragin E, Chatzimichali EA, Wright CF, Hurles ME, Firth HV et al.

    Nucleic acids research 2014;42;Database issue;D993-D1000

  • DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.

    Swaminathan GJ, Bragin E, Chatzimichali EA, Corpas M, Bevan AP et al.

    Human molecular genetics 2012;21;R1;R37-44

  • DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.

    Firth HV, Richards SM, Bevan AP, Clayton S, Corpas M et al.

    American journal of human genetics 2009;84;4;524-33

  • The role of insulin dissociation from its endosomal receptor in insulin degradation.

    Bevan AP, Seabright PJ, Tikerpae J, Posner BI, Smith GD and Siddle K

    Molecular and cellular endocrinology 2000;164;1-2;145-57

  • Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.

    Foggensteiner L, Bevan AP, Thomas R, Coleman N, Boulter C et al.

    Journal of the American Society of Nephrology : JASN 2000;11;5;814-27

  • Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes.

    Bevan AP, Krook A, Tikerpae J, Seabright PJ, Siddle K and Smith GD

    The Journal of biological chemistry 1997;272;43;26833-40

  • Increased glycogen synthesis in rat diaphragm following chloroquine treatment in vivo.

    Bevan AP and Smith GD

    Biochemical Society transactions 1997;25;3;462S

  • Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.

    Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP et al.

    The Journal of biological chemistry 1997;272;30;19000-7

  • A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo.

    Drake PG, Bevan AP, Burgess JW, Bergeron JJ and Posner BI

    Endocrinology 1996;137;11;4960-8

  • Intracellular signal transduction: The role of endosomes.

    Bevan AP, Drake PG, Bergeron JJ and Posner BI

    Trends in endocrinology and metabolism: TEM 1996;7;1;13-21

  • Peroxovanadium compounds: biological actions and mechanism of insulin-mimesis.

    Bevan AP, Drake PG, Yale JF, Shaver A and Posner BI

    Molecular and cellular biochemistry 1995;153;1-2;49-58

  • Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats.

    Yale JF, Lachance D, Bevan AP, Vigeant C, Shaver A and Posner BI

    Diabetes 1995;44;11;1274-9

  • Chloroquine augments the binding of insulin to its receptor.

    Bevan AP, Christensen JR, Tikerpae J and Smith GD

    The Biochemical journal 1995;311 ( Pt 3);787-95

  • Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling.

    Bevan AP, Burgess JW, Drake PG, Shaver A, Bergeron JJ and Posner BI

    The Journal of biological chemistry 1995;270;18;10784-91

  • In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency.

    Bevan AP, Burgess JW, Yale JF, Drake PG, Lachance D et al.

    The American journal of physiology 1995;268;1 Pt 1;E60-6

  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D et al.

    The Journal of biological chemistry 1994;269;6;4596-604

  • Pharmacological doses of insulin equalize insulin receptor phosphotyrosine content but not tyrosine kinase activity in plasmalemmal and endosomal membranes.

    Burgess JW, Bevan AP, Bergeron JJ and Posner BI

    Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70;10-11;1151-8

  • Interpretation of genomic copy number variants using DECIPHER.

    Corpas M, Bragin E, Clayton S, Bevan P and Firth HV

    Current protocols in human genetics 2012;Chapter 8;Unit 8.14

  • An overview of Ensembl.

    Birney E, Andrews TD, Bevan P, Caccamo M, Chen Y et al.

    Genome research 2004;14;5;925-8

  • Ensembl 2004.

    Birney E, Andrews D, Bevan P, Caccamo M, Cameron G et al.

    Nucleic acids research 2004;32;Database issue;D468-70

  • Ensembl 2002: accommodating comparative genomics.

    Clamp M, Andrews D, Barker D, Bevan P, Cameron G et al.

    Nucleic acids research 2003;31;1;38-42

  • Insulin signalling.

    Bevan P

    Journal of cell science 2001;114;Pt 8;1429-30

  • Internalization of hepatic glucagon receptors is not accompanied by a significant movement of Gs alpha.

    Pollock K, Forder R, Creba J, Bevan P and Smith G

    Biochemical Society transactions 1990;18;3;474-5

  • 'Your DNA, Your Say': global survey gathering attitudes toward genomics: design, delivery and methods.

    Middleton A, Niemiec E, Prainsack B, Bobe J, Farley L et al.

    Personalized medicine 2018

  • DECIPHER: database for the interpretation of phenotype-linked plausibly pathogenic sequence and copy-number variation.

    Bragin E, Chatzimichali EA, Wright CF, Hurles ME, Firth HV et al.

    Nucleic acids research 2014;42;Database issue;D993-D1000

  • DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.

    Swaminathan GJ, Bragin E, Chatzimichali EA, Corpas M, Bevan AP et al.

    Human molecular genetics 2012;21;R1;R37-44

  • DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.

    Firth HV, Richards SM, Bevan AP, Clayton S, Corpas M et al.

    American journal of human genetics 2009;84;4;524-33

  • An overview of Ensembl.

    Birney E, Andrews TD, Bevan P, Caccamo M, Chen Y et al.

    Genome research 2004;14;5;925-8

  • Ensembl 2004.

    Birney E, Andrews D, Bevan P, Caccamo M, Cameron G et al.

    Nucleic acids research 2004;32;Database issue;D468-70

Bevan, Paul
Paul's Timeline
2004

Start of Decipher project http://decipher.sanger.ac.uk/

2000

Started at the Wellcome Sanger Institute in Web and IT

1998

Postdoctoral researcher in Department of Medical Genetics, University of Cambridge

1996

Postdoctoral researcher in Department of Clinical Biochemistry, University of Cambridge

1991

Postdoctoral researcher at McGill University, Montreal, Canada

Awarded PhD in Medical Biochemistry

1987

Awarded BSc in Applied Biochemistry