Sam Behjati | Group Leader and Wellcome Trust Intermediate Clinical Fellow

Behjati, Sam

I am a Paediatrician Scientist and Group Leader working across Cellular Genetics and Cancer. I am broadly interested in the developmental origins of cancer, especially of childhood cancer. To that end we combine cutting single cell transcriptomics with cancer genomics.


  • Spatiotemporal immune zonation of the human kidney.

    Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW et al.

    Science (New York, N.Y.) 2019;365;6460;1461-1466

  • Decoding human fetal liver haematopoiesis.

    Popescu DM, Botting RA, Stephenson E, Green K, Webb S et al.

    Nature 2019;574;7778;365-371

  • Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

    Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A et al.

    Science (New York, N.Y.) 2018;361;6405

  • Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

    Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ et al.

    Science (New York, N.Y.) 2018;361;6402;594-599

  • Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

    Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ et al.

    Nature communications 2018;9;1;2378

  • Recurrent rearrangements of FOS and FOSB define osteoblastoma.

    Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC et al.

    Nature communications 2018;9;1;2150

  • Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

    Collord G, Martincorena I, Young MD, Foroni L, Bolli N et al.

    British journal of haematology 2019;184;4;676-679

  • Mapping human development at single-cell resolution.

    Behjati S, Lindsay S, Teichmann SA and Haniffa M

    Development (Cambridge, England) 2018;145;3

  • The driver landscape of sporadic chordoma.

    Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB et al.

    Nature communications 2017;8;1;890

  • Genetics: Taking single-cell transcriptomics to the bedside.

    Behjati S and Haniffa M

    Nature reviews. Clinical oncology 2017;14;10;590-592

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Behjati S, Tarpey PS, Haase K, Ye H, Young MD et al.

    Nature communications 2017;8;15936

  • Molecular diagnoses of century-old childhood tumours.

    Virasami A, Farndon SJ, McDermott U, Sebire N and Behjati S

    The Lancet. Oncology 2017;18;5;e237

  • Retracing embryological fate.

    Behjati S

    Science (New York, N.Y.) 2016;354;6316;1109

  • Mutational signatures of ionizing radiation in second malignancies.

    Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS et al.

    Nature communications 2016;7;12605

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC et al.

    Nature 2014;513;7518;422-425

  • Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

    Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P et al.

    Nature genetics 2014;46;4;376-379

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N et al.

    Nature genetics 2013;45;12;1479-82

  • Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.

    Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC et al.

    Nature genetics 2013;45;8;923-6

Behjati, Sam
Sam's Timeline

Liddy Shriver Early Research Award | Connective Tissue Oncology Society

Honorary Consultant Paediatric Oncologist | Addenbrooke's

Dr Simon Newell Early Career Investigator of the Year (Sparks) award | Royal College of Paediatrics and Child Health


Group Leader | Sanger


Science & SciLifeLab Prize for Young Scientists

Wellcome Intermediate Clinical Fellowship | Sanger | University of Cambridge

Robert J. Arceci Innovation Award | St. Baldrick’s Foundation


Donald Paterson Prize | Royal College of Paediatrics and Child Health


PhD | Wellcome Clinical Research Fellow | Sanger | University of Cambridge


Academic Clinical Fellow | UCL Great Ormond Street Institute of Child Health