Syd Barthorpe | Senior Scientific Manager

Barthorpe, Syd

Syd manages the high-throughput operations within the Garnett Group. These include drug sensitivity screens both single agents and combinations in cell line and organoids models as well as CRISPR knockout screens. He has over ten years of cancer research experience working on high-throughput genomic & cell based projects at the Sanger Institute. 

In addition Syd helped to establish the Cell Model Passports, a website providing annotation, genomics and functional datasets for the cancer models used as part of the Cancer Dependency Map at Sanger.

Publications

  • Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models.

    van der Meer D, Barthorpe S, Yang W, Lightfoot H, Hall C et al.

    Nucleic acids research 2019;47;D1;D923-D929

  • A Landscape of Pharmacogenomic Interactions in Cancer.

    Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP et al.

    Cell 2016;166;3;740-754

  • Systematic identification of genomic markers of drug sensitivity in cancer cells.

    Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A et al.

    Nature 2012;483;7391;570-5

  • Patterns of somatic mutation in human cancer genomes.

    Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C et al.

    Nature 2007;446;7132;153-8

  • Systematic identification of genomic markers of drug sensitivity in cancer cells.

    Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A et al.

    Nature 2012;483;7391;570-5

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

    Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G et al.

    Nature 2010;463;7279;360-3

  • A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

    Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S et al.

    Nature genetics 2009;41;5;535-43

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

    van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G et al.

    Nature genetics 2009;41;5;521-3

  • X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.

    Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE et al.

    Nature genetics 2008;40;6;776-81

  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

    Tarpey PS, Raymond FL, Nguyen LS, Rodriguez J, Hackett A et al.

    Nature genetics 2007;39;9;1127-33

  • Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.

    Field M, Tarpey PS, Smith R, Edkins S, O'Meara S et al.

    American journal of human genetics 2007;81;2;367-74

  • Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.

    Raymond FL, Tarpey PS, Edkins S, Tofts C, O'Meara S et al.

    American journal of human genetics 2007;80;5;982-7

  • Patterns of somatic mutation in human cancer genomes.

    Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C et al.

    Nature 2007;446;7132;153-8

  • Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.

    Tarpey PS, Raymond FL, O'Meara S, Edkins S, Teague J et al.

    American journal of human genetics 2007;80;2;345-52

  • Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation.

    Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S et al.

    American journal of human genetics 2006;79;6;1119-24

  • Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

    Ikediobi ON, Davies H, Bignell G, Edkins S, Stevens C et al.

    Molecular cancer therapeutics 2006;5;11;2606-12

  • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

    Hunter C, Smith R, Cahill DP, Stephens P, Stevens C et al.

    Cancer research 2006;66;8;3987-91

  • Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.

    Bignell G, Smith R, Hunter C, Stephens P, Davies H et al.

    Genes, chromosomes & cancer 2006;45;1;42-6

  • Somatic mutations of the protein kinase gene family in human lung cancer.

    Davies H, Hunter C, Smith R, Stephens P, Greenman C et al.

    Cancer research 2005;65;17;7591-5

Barthorpe, Syd
Syd's Timeline
2009

Joined GDSC group at Sanger.

2003

Joined Sanger Institute; Cancer Genome Project.

2002

BSc, University College London