Dr Jennifer Asimit | MRC Methodology Research Fellow - Statistical Geneticist

This person is a member of Sanger Institute Alumni.

Asimit, Jennifer

My research interests lie in statistical methodology development for the analysis of genetic data, including next-generation sequencing. Currently, I am focused on methods for the overlap analysis of a collection of traits, though other interests include rare variant analyses and trans-ethnic fine-mapping. I am also interested in developing analysis approaches that incorporate prior biological knowledge, such as functional annotation and biological pathways.

I have developed methods and software for rare variant association analyses, ARIEL and AMELIA, as well as for the overlap analysis of traits, BOAT.

Publications

  • Trans-ethnic study design approaches for fine-mapping.

    Asimit JL, Hatzikotoulas K, McCarthy M, Morris AP and Zeggini E

    European journal of human genetics : EJHG 2016;24;9;1330-6

  • A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.

    Asimit JL, Panoutsopoulou K, Wheeler E, Berndt SI, GIANT consortium et al.

    Genetic epidemiology 2015;39;8;624-34

  • Genome-wide association analysis of imputed rare variants: application to seven common complex diseases.

    Mägi R, Asimit JL, Day-Williams AG, Zeggini E and Morris AP

    Genetic epidemiology 2012;36;8;785-96

  • Imputation of rare variants in next-generation association studies.

    Asimit JL and Zeggini E

    Human heredity 2012;74;3-4;196-204

  • ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.

    Asimit JL, Day-Williams AG, Morris AP and Zeggini E

    Human heredity 2012;73;2;84-94

  • An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity.

    Asimit J, Day-Williams A, Zgaga L, Rudan I, Boraska V and Zeggini E

    European journal of human genetics : EJHG 2012;20;6;709-12

  • A combined functional annotation score for non-synonymous variants.

    Lopes MC, Joyce C, Ritchie GR, John SL, Cunningham F et al.

    Human heredity 2012;73;1;47-51

  • Regression models, scan statistics and reappearance probabilities to detect regions of association between gene expression and copy number.

    Asimit JL, Andrulis IL and Bull SB

    Statistics in medicine 2011;30;10;1157-78

  • Rare variant association analysis methods for complex traits.

    Asimit J and Zeggini E

    Annual review of genetics 2010;44;293-308

  • Trans-ethnic study design approaches for fine-mapping.

    Asimit JL, Hatzikotoulas K, McCarthy M, Morris AP and Zeggini E

    European journal of human genetics : EJHG 2016;24;9;1330-6

  • A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.

    Asimit JL, Panoutsopoulou K, Wheeler E, Berndt SI, GIANT consortium et al.

    Genetic epidemiology 2015;39;8;624-34

  • Genome-wide association analysis of imputed rare variants: application to seven common complex diseases.

    Mägi R, Asimit JL, Day-Williams AG, Zeggini E and Morris AP

    Genetic epidemiology 2012;36;8;785-96

  • An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity.

    Asimit J, Day-Williams A, Zgaga L, Rudan I, Boraska V and Zeggini E

    European journal of human genetics : EJHG 2012;20;6;709-12

  • A combined functional annotation score for non-synonymous variants.

    Lopes MC, Joyce C, Ritchie GR, John SL, Cunningham F et al.

    Human heredity 2012;73;1;47-51

  • ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.

    Asimit JL, Day-Williams AG, Morris AP and Zeggini E

    Human heredity 2012;73;2;84-94

  • Imputation of rare variants in next-generation association studies.

    Asimit JL and Zeggini E

    Human heredity 2012;74;3-4;196-204

  • Regression models, scan statistics and reappearance probabilities to detect regions of association between gene expression and copy number.

    Asimit JL, Andrulis IL and Bull SB

    Statistics in medicine 2011;30;10;1157-78

Asimit, Jennifer
Jennifer's Timeline
2013

MRC Methodology Research Fellow, Metabolic Disease group (Dr. Inês Barroso), Wellcome Trust Sanger Institute

2010

Post-doctoral Fellow, Analytical Genomics of Complex Traits group (Dr. Eleftheria Zeggini), Wellcome Trust Sanger Institute

2006

Canadian Breast Cancer Foundation Post-doctoral Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada in the team of Dr. Shelley Bull

PhD in Statistics (Analysis of Point Processes with Applications to Reaction Time Experiments), Western University, London, Ontario, Canada

Canadian Journal of Statistics Award for 2005 for the paper: JL Asimit and WJ Braun (2005) “Third order point process intensity estimation for reaction time experiment data”, The Canadian Journal of Statistics, Vol. 33, No 2, pp. 243-257.

2002

MSc in Statistics, Western University, London, Ontario, Canada

2001

BSc in Mathematics and Statistics (double major), University of Winnipeg, Manitoba, Canada