Clinical PhD Programme
Clinical PhD fellowships are available for clinical health professionals with an aptitude for research and the potential to become future leaders in genomics, biomedicine and healthcare science.
The application process for the 2022 intake of the Wellcome Sanger Institute Clinical PhD Programme is now closed. The application process for the 2023 intake will open in Autumn 2022, date tbc.
The Wellcome Sanger Institute Clinical PhD Programme is a 3-year programme, run in partnership with the PhD Programme for Health Professionals at the Universities of Cambridge and East Anglia.
The PhD Programme for Health Professionals aims to provide high-quality research training to clinical health professionals with an aptitude for research, to enable them to become future leaders in medical and healthcare science.
The Programme offers training opportunities with world-leading researchers in outstanding environments, spanning basic science, translational medicine, and interdisciplinary, behavioural and applied health research. All we are looking for in our trainees is the pursuit of research excellence, hard work and the will to make a difference to health.
Up to seven fellowships are available each year, two of which are funded by the Sanger Institute. To be eligible to apply for the fellowships, you must be qualified in clinical, dental or veterinary medicine, or be a non-medical health professional registered with a national professional regulatory body in the UK (please see FAQs for eligibility). In addition, medical, dental and veterinary applicants must be in a training grade (i.e., not a Consultant, University Faculty or equivalent position). Non-medical health professionals may be at different stages in their clinical careers, but should possess sufficient relevant research experience to be able to take advantage of this unique opportunity. They also would not be expected to be University Faculty or equivalent position. Salaries are maintained in accordance with recognised UK clinical scales.
It is important to note that fellowships supported by the Universities of Cambridge and East Anglia are only open to health professionals in clinical training in the UK, whereas Sanger Institute funded fellowships are open to health professionals in clinical training both in the UK and overseas. However, all successful candidates must be registered with the appropriate national professional regulatory body in the UK prior to commencement of the fellowship.
For medical graduates who do not hold academic clinical fellowships (ACFs) and non-medical health professionals, there is the opportunity to undertake a three-month pre-doctoral research placement. During this time, you can undertake mini-projects with research groups in your areas of interest, thereby enabling you to make an informed choice of PhD project and supervisor(s).
For more information about research opportunities at the Sanger Institute, please see some examples of Potential PhD projects below.
Those health professionals who choose to carry out their PhD at the Sanger Institute are expected to attend training courses in transferable and general research skills, participate in the students’ journal club, present their work regularly and attend seminars. They also have to present their work annually at a Summer Symposium held jointly with the other students on the PhD Programme for Health Professionals. In addition, the Directors of the Programme arrange ‘clinical’ mentoring for all Programme students. Students on the Programme are able to hold honorary contracts at Addenbrooke’s Hospital in order to maintain their clinical links.
Within the first few months of their PhD, in common with the other students on the PhD Programme for Health Professionals, our clinical students have to prepare a research proposal for their project in the form of a ‘Project Grant Application’. This is discussed with a panel of leading academics connected with the Programme. Student progress is monitored by assessment of their first year report and by thesis committee meetings, which take place every six months.
For information on how to make an application to our Clinical PhD Programme please go to the How to apply section below.
To see what some of our former clinical PhD students have achieved during their time at the Institute, and since, please go to the Case studies section below.
University of Cambridge affiliation
Students at the Wellcome Sanger Institute are awarded a University of Cambridge PhD degree.
The Wellcome Sanger Institute was granted affiliation with the University of Cambridge as a ‘University Partner Institution’ in 1995. All postgraduate students at the Institute are registered with the University and are members of a Cambridge College. This allows our students to take an active part in the University’s academic and social life and brings many benefits such as access to events/courses run by University departments and the Postgraduate School of Life Sciences, and access to University facilities such as the library and the careers service.
Potential PhD projects
The Wellcome Sanger Institute is at the forefront of experimental, computational and translational genomic research. Our Faculty members use large-scale genomic tools to investigate important global health problems such as cancer, malaria and infectious disease. Please visit our potential supervisors page for information on Faculty members and their research areas.
Examples of potential PhD projects include:
- Exploring synthetic lethality for cancer drug discovery – Dr David Adams
- Using single-cell genomics and DNA sequencing to identify novel drug targets for inflammatory bowel disease – Dr Carl Anderson
- Understanding brain development and disease using spatial transcriptomics – Dr Omer Bayraktar
- Finding the origins of human cancer – Dr Sam Behjati
- Using functional genomics to understand patient heterogeneity within disease and in response to treatment – Dr Emma Davenport
- Oncology drug target discovery using functional genomics – Dr Mathew Garnett
- Developmental immune programmes in tissue morphogenesis and disease – Prof Muzz Haniffa
- Informing therapeutic strategies for neurodevelopmental disorders through experimental perturbation of gene regulation in cellular models – Dr Matt Hurles
- Functional and metagenomic analysis of human intestinal microbiome during health and irritable bowel syndrome – Dr Trevor Lawley
- Using single cell genomics to investigate malaria transmission in Africa – Dr Mara Lawniczak
- Understanding the effect of ageing on human oocytes using multi-omics approaches – Dr Raheleh Rahbari
- Deciphering immunity using single cell genomics – Dr Sarah Teichmann
- Comparing human B cell repertoires induced by oral vaccination or by natural infection: towards the development of therapeutic antibodies – Prof Nick Thomson and Prof Steve Baker
Women’s health genomics – Dr Roser Vento-Tormo
Supervision and monitoring
Each student has a PhD supervisor from within the Institute’s Faculty who provides day-to-day supervision of their research. They also benefit from a co-supervisor (external adviser), selected from the University of Cambridge, who works in a similar or complementary discipline and meets regularly with the student.
Postgraduate students at the Institute are monitored and managed by the Committee of Graduate Studies, which meets regularly, together with support from dedicated administrative personnel. Monitoring of each student’s progress is achieved through their first year report, second year thesis plan and thesis committee meetings which take place every six months.
The thesis committee, which consists of the principal supervisor, the co-supervisor (external adviser) and one or two Sanger Institute Faculty members, primarily serves as a scientific advisory board for the student throughout their PhD work. Its function is to offer comments, advice and support to the student in order to ensure that the thesis can be completed in an appropriate time frame and with the best possible output. In addition to the student’s own research group, the thesis committee provides an independent forum for scientific discussion.
Students are expected to complete their research and submit their thesis within the three-year time frame of the award. At this point each student must give a formal Sanger Institute seminar.
Students on the Clinical PhD Programme are encouraged to attend training courses in transferable and general research skills such as:
- Health and safety training
- Graduate lecture series (approx 30 lectures by Sanger Faculty members)
- Computational skills training
- Bioinformatics courses and workshops
- Next generation sequencing
- Research integrity, reproducible research and ethics workshops
- Presentation skills
- Scientific writing skills
- Communication and public engagement workshop
A wide range of courses are also run on site for which students are eligible. As members of the University of Cambridge, students have access to lecture courses run by University departments, courses run by the Postgraduate School of Life Sciences and to University facilities such as the library and the careers service. There is also an excellent library on site at the Institute.
There is a fortnightly journal club which all students, except those in their final year, are expected to attend, and students are expected to participate in the programme of journal clubs and research talks within their own research division.
There is a very active academic seminar programme on site. Also students have the opportunity to meet and have informal discussions over lunch with speakers in our Distinguished Lecture Series. In addition, relevant seminar programmes within the University are widely advertised, and students are encouraged to attend.
All clinical PhD students have the opportunity to present their work regularly to their group. They also have to present their work annually at a Summer Symposium held jointly with the other students on the PhD Programme for Health Professionals. In the final year, once students have submitted their thesis, they are required to present their work at a Sanger Institute seminar. In addition, students are encouraged to present their work at both national and international scientific meetings, and we provide up to £1000 per year to enable them to attend such meetings.
Students at the Institute are encouraged to organise their own events such as the EBI-Sanger Cambridge PhD Symposium (eSCAMPS). This meeting brings together students from the whole Cambridge area and gives them the opportunity to present their work to their peers and listen to a number of world renowned keynote speakers. Organising such a meeting (liaising with speakers, seeking sponsorship, managing logistical arrangements etc) allows the students involved to develop their networking, communication and management skills.
How to apply
For more information about the Programme, and details on how to apply, go to: PhD Programme for Health Professionals at the Universities of Cambridge and East Anglia.
In brief, applications must be made via the University of Cambridge Postgraduate Admissions on-line applicant portal.
The application process for the 2022 intake of the Institute’s Clinical PhD Programme and the PhD Programme for Health Professionals at the Universities of Cambridge and East Anglia is now closed. The application closing date was Monday 17th January 2022 (midday GMT).
Applicants will be shortlisted and interviewed by a selection panel consisting of the Programme Directors, Faculty members from the University of East Anglia, University of Cambridge Department of Veterinary Medicine and Wellcome Sanger Institute, and also a selection of Theme Leads and Principal Investigators from the Programme. A Director of another Clinical PhD Programme may be invited to join the panel.
Some of our former clinical PhD students:
Vanessa Wong (2010 intake)
PhD project: ‘Salmonella Typhi: a global perspective based on genomics’, supervised by Professor Gordon Dougan.
PhD publications: Seventeen publications, including one first author Nature Genetics paper and six additional first author publications.
Awards/prizes: Furness Prize for Science Communication, Royal College of Pathologists in 2011, Oswald Morton Essay Prize, Pharmaceutical Medicine and Research Section, Royal Society of Medicine in 2012, NIHR Cambridge BRC Research Capability Funding Clinical Research Fellowship in 2014, Gold Medal Research Award, Royal College of Pathologists in 2015, Winner of Young Investigator Award, 2016 Spring Meeting, Academy of Medical Sciences, ACT Research Award 2019.
Current position: Consultant in Infectious Diseases and Microbiology, Addenbrooke’s Hospital, Cambridge.
Sam Behjati (2011 intake)
PhD project: ‘Massively parallel sequencing of benign and malignant human tumours’, supervised by Professor Mike Stratton and Dr Peter Campbell.
PhD publications: 18 publications, including three first/joint first author Nature Genetics papers, one first author Nature paper and four additional joint first author papers.
Awards/prizes: Conquer Cancer Foundation ASCO Merit Award in 2014, Donald Paterson prize, Royal College of Paediatrics and Child Health in 2015, St. Baldrick’s Foundation Robert J. Arceci Innovation Award in 2016, Science & SciLifeLab Prize for Young Scientists in Genomics and Proteomics in 2016.
Current position: Group Leader, Sanger Institute and Wellcome Intermediate Clinical Fellow, University of Cambridge.
Tom McKerrell (2012 intake)
PhD project: ‘‘A Study of Myeloid Malignancies and their Pre-Clinical Evolution’ supervised by Dr George Vassiliou. Major findings include the identification of age-related clonal haemopoiesis driven by leukaemia-associated mutations in healthy individuals.
PhD publications: Six publications, including four first author publications.
Awards/prizes: Wellcome Sanger Institute Early Career Innovation Award 2014.
Current position: NIHR Academic Clinical Lecturer in Haematology, University of Cambridge.
Equality and diversity
The Wellcome Sanger Institute values the diversity of its employees, students, visitors and collaborators. The diversity of our workforce is of critical importance in drawing together the broad range of skills and experience we depend on to conduct world class science and support biomedical discovery.
We therefore believe that it is in the best interests of the Institute and those that benefit from its work to attract, retain and develop a diverse pool of talent and to provide a working environment that encourages and supports excellent performance from all who work here. We aim to achieve this by:
- Providing equality of opportunity in recruitment, selection, training, promotion and career management
- The elimination of unlawful discrimination
- The promotion of diversity and equality
- Stimulating interest in scientific careers through our Connecting Science and Public Engagement Programme
- Developing an Equality, Diversity and Inclusion Strategy to further embed the principles of Equality & Diversity in the work and people of the Institute and monitoring the outcome of this
Selection of PhD Students
The Institute’s PhD programmes aspire to be equally accessible to all applicants irrespective of gender, country of origin, ethnicity, colour, religion, age, disability or factors other than academic matters. Applications are welcomed from candidates worldwide and will be considered exclusively on merit. To reduce financial and geographic barriers to admission, we provide payment of all University tuition fees along with a generous stipend/salary. Indeed many of our students come from low and middle income countries such as Malawi, Uganda, Kenya, Mexico, Colombia, China, Vietnam, Pakistan and Bangladesh. Also, our typical annual intake of students is roughly half male, half female.
Wherever practical the Institute will adopt a flexible approach to prevent any disadvantage that could arise for prospective PhD students from career and/or study gaps that may be due to maternity, paternity, adoption and other caring responsibilities or periods of illness or disability.
Equality in Science
The Sanger Institute and its campus neighbour, the European Bioinformatics Institute (EBI), run an active Equality in Science Programme aimed at highlighting and addressing issues affecting the gender imbalance that occurs in the senior ranks of science. This includes consideration of work-life balance issues that affect both male and female scientists and a regular Careers Day for everyone on campus with a chance to speak with funders and learn about a range of scientific careers. The programme is also looking at issues affecting marginalised groups such as LGBT+, BME and disabled scientists.
In April 2020 we were awarded the Athena SWAN Silver award, having been one of the first research institutes to achieve the Bronze award in April 2014.
Balancing PhD studies with family life
We recognise that for some PhD students, there will be a need to allow time and flexibility to deal with caring responsibilities (e.g. for children and/or relatives) and we want to provide a PhD programme that is supportive of these needs, whilst not compromising on giving you an excellent start to your scientific career. This includes provisions to pause studies for maternity, paternity, adoption or shared parental leave, access to our onsite nursery facilities and a flexible approach to work.
Since Sanger Institute PhD students are registered at the University of Cambridge, they are also able to access childcare services provided by the University.
If you have any queries about balancing PhD studies with family life, please contact the Graduate Programme Office.