METACARPA performs scalable meta-analysis between genetic association studies, both effect-size based and p-value based, while correcting for unknown sample overlap.

Meta-analysis allows to summarize association results across several studies, but assumes independence of samples. Lin and Sullivan (2009) have developed a method that accounts for overlapping samples when the degree of overlap is known. Province and Borecki (2013) use the tetrachoric correlation of transformed p-values to estimate relatedness in a p-value based meta-analysis. We implement this method and adapt this estimator to Lin and Sullivan’s to provide a correlated meta-analysis of both p-values and effect sizes.

Download and Installation

The software source is free to download and use from the author's GitHub account.

Simulations are available in a separate repository.

Learn and Support

You will find a simple introduction to the software in the README at the root of the bitbucket repository. Details on how the software behaves under various study designs can be found in the simulation repository.

License and Citation

This software is open source. You are free to fork and modify the software, provided you give credit to the original author.

If you make use of this software in your research please cite as follows : Southam L., Gilly A., Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits. Nat Commun. 2017 May 26;8:15606. doi: 10.1038/ncomms15606.


For all enquiries and questions, please contact Arthur Gilly directly.


Sanger Contributors