The Cancer Gene Census is a list of genes with substantial published evidence in Oncology. Regularly updated by the COSMIC curation team, who are continuously immersed in the literature, hundreds of genes are now described with a variety of mutation mechanisms across all human cancer types. Acceptance criteria are literature-based, requiring indisputable clear mutation patterns in specified cancer diseases from at least two independent studies from different groups. Statistical interpretations of broad genomic data are not included, making the Census a conservative but very high-confidence list. This list is used to drive expert curation in the COSMIC project, and Census genes are highlighted in the COSMIC website with a small icon.