Dr Nicole Wheeler

Data Scientist

Nicole is a Data Scientist at the Centre for Genomic Pathogen Surveillance. Her focus is on developing high-throughput computational methods for understanding adaptation in bacterial pathogens, and flagging high-risk strains. She combines a background in biochemistry and genetics with experience in statistics and machine learning to find new ways to gain insight from genome sequence data.

During my PhD I developed a bioinformatic method which weights mutations in protein coding genes based on their predicted impact on protein function. I then collaborated with a variety of groups to apply this method to the study of the genomic changes that occur during niche adaptation.

My current work is focussed on linking genotype to phenotype in bacterial pathogens using comparative genomics, genome-wide association studies and machine learning. This work is a balance of developing new methods, and applying them to questions regarding the evolution of virulence in a range of bacterial species. I am particularly interested in building algorithms that identify high-risk strrains of bacteria that are resistant to antibiotics, more likely to cause severe infections, or more likely to spread globally. I’ve been applying these insights to the development of ways to recognise emerging pathogens using genome sequence data.

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NEWS: @WHO report supports global use of genetic sequencing to fight antimicrobial resistance #AMR

Read more 👉 https://www.bdi.ox.ac.uk/news/who-report-supports-global-use-of-genetic-sequencing-to-fight-antimicrobial-resistance


We are thrilled to have been involved in the development of new @who report on whole genome sequencing for surveillance of antimicrobial resistance https://www.who.int/publications/i/item/9789240011007

Just watched Jacinda's FB live from tonight and discovered that she answers all the kids' letters sent to her as a top priority so they have a great first interaction with our political system. And I'm like OH COME THE FUCK ON NO ONE CAN BE THIS NICE