Thierry Voet, PhD

Group leader

Thierry Voet's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable the exploration of DNA-mutation, the genetic differences between cells in a person's body and the relation of this diversity to disease.

We are developing methods to determine all classes of genetic variants in the DNA of a single cell, as well as the RNA molecules the cell transcribes, using next-generation sequencing. We are applying our methods to study mutagenesis (the mechanism and rate of genetic mutation), somatic genetic heterogeneity (the degree of genetic difference between individual cells in a person’s body) and their effect on disease. Using our methods, we are probing for the extent, nature and biology of cellular heterogeneity in health and disease.

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