Dr Frank Schwach
Senior Computational Biologist
My main project is the development of the software tools and web portal supporting PlasmoGEM - a genome-wide resource of gene modification vectors. The software is used to automate the gene modification design process, track constructs though the wet lab pipeline and analyse deep-sequencing data for quality control purposes. In addition, I provide bioinformatics support for various projects in the lab, including transcriptomics and proteomics assays.
I obtained a PhD in plant virology at the University of Hamburg (Germany) in 2002 before joining the lab of David Baulcombe at the Sainsbury Laboratory in Norwich (UK), working on the mechanisms of small-RNA-mediated anti-viral gene silencing. With the advent of next-generation sequencing, I shifted my focus to the computational analysis of high-throughput sequence data. I continued this work at the University of East Anglia, developing a collection of web-based tools for the analysis of large-scale small RNA data. In December 2009, I joined the Billker lab to support the PlasmoGEM team.