PhD Student in Computational Biology - Focus on somatic mutations in pre-malignant lung disease and accelerated ageing phenotypes.
I am a 2nd year PhD student jointly supervised by Inigo Martincorena and Peter Campbell, particularly interested in understanding the mechanisms underlying early cancer evolution and prevention. In particular, I am specializing in computational analysis of genomic data from high-throughput sequencing, with the goal to advance my understanding about the earliest steps of tumourigenesis occuring in healthy individuals. In line with this, I am working on the characterisation of the landscape of somatic variation in the proximal and distal airway of lungs from individuals with previous smoking histories. In addition, I am interested in the contribution of somatic variation to ageing, exploring the routes and features of accelerated ageing phenotypes (progeroid syndromes). I am curious to learn about entrepreneurship in biotechnology and health, including but not limited to key strategic, technical, financial and commercial issues linked to the creation and development of an idea into a start-up.
Feel free to get in touch – happy to discuss anytime 🙂
My timeline
Science & Management (MBA) Fellow - Collège des Ingénieurs
PhD Student - Dr. Inigo Martincorena, Dr. Peter Campbell - Cancer, Ageing and Somatic Mutations - Wellcome Sanger Institute
Visiting Student - Prof. Dr. C. Curtis, Dr. K. Karlsson - Cancer Computational and Systems Biology Group - Stanford University
Graduate Research Student - Prof. Dr. O. Stegle, Dr. N. Casiraghi, Dr. H. Susak - Statistical Genomics and Systems Genetics - DKFZ German Cancer Research Center
Visiting Student - Prof. Dr. C. Swanton, Dr. S. Turajlic - Cancer Evolution and Genome Instability Laboratory - The Francis Crick Institute
Master of Science - University of Heidelberg
Graduate Student Research Assistant - Prof. Dr. M. v. Knebel-Doeberitz, PD Dr. M. Kloor - Department of Applied Tumor Biology - University Hospital Heidelberg
Bachelor of Science - University of Heidelberg
Connect with me on Twitter
;
Hi twitter folks! We are #hiring a postdoc to work on the origin of lung cancer within an exciting @CRUKresearch project between @lungsforliving and @sangerinstitute. Come and work with the fantastic Peter Campbell - please spread the word and #share! 🥳
https://sanger.wd3.myworkdayjobs.com/en-US/WellcomeSangerInstitute/job/Postdoctoral-Fellow_JR100287
Happy day-our latest manuscript is out today @NatureMedicine!
Thanks to the amazing team:
@SteinfeldtJakob @pietznerm @omicscience @MikaKivimaki @CaptainSysBio John Deanfield & Ulf Landmesser + many more
@berlinnovation @ChariteBerlin @ucl
Paper: https://www.nature.com/articles/s41591-022-01980-3
(1/9)
If anyone had a doubt that somatic mosaicism is the next frontier in human genetics, here’s a case study:
Exomes of 30K patients delivers the same gene that Campbell group discovered with somatic profiling of 30.
30K vs 30 🤯
https://www.nature.com/articles/s41586-021-03974-6 https://twitter.com/Regeneron/status/1552411907826524165
#BREAKING In the largest sequencing study to date to better understand how genetic mutations can cause or prevent liver disease, @RegeneronDNA uncovered rare genetic mutations in the CIDEB gene associated with protection from nonalcoholic liver disease and nonalcoholic cirrhosis.