Bram Prins

Statistical Geneticist


This person is a member of Sanger Institute Alumni.

Bram is a statistical geneticist interested in using and eventually developing statistical genetics and bioinformatics approaches to unravel biological mechanisms underlying complex diseases, with a focus on inflammatory and cardiometabolic phenotypes. He is a member of the Analytical Genomics of Complex Traits group at the Wellcome Trust Sanger Institute.

The central theme in my current work is unlocking the mechanisms by which human genetic variation influences complex traits and predisposes to disease.

I use various types of large-scale genetic datasets, ranging from ordinary exome and GWAS chip data, to whole genome sequences to uncover rare and common variation underlying various polygenic traits and diseases and leverage this knowledge to understand comorbidity between diseases. Most of my work is done in the context of large-scale consortia, for which I am involved several efforts of the CHARGE consortium, Spirometa, UKBiLEVE, ICBP, MAGIC, DIAMANTE and YGEN.

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