Dr Zhengzheng Sophia Liang
This person is a member of Sanger Institute Alumni.
I am interested in the molecular basis underlying animal behavior. My previous projects focus on how variations in brain gene expression mediate distinct behavioral response in a social group.
At Sanger, I was supported by a EMBO long-term fellowship to work with Dr Logan and together we tackled a puzzle in epigenetics: why parentally biased control of gene expression is maintained in the mammalian brain. By mapping a high-resolution allelic imbalance landscape in the mouse olfaction system, I identified and validated a candidate gene Trappc9 that shows a strong maternal expression bias exclusively in the brain, and followed it up by phenotypical characterization of the knockout mice lacking this key gene.