Federico Abascal

Staff Scientist

Federico’s current research interest is in the study of somatic mutation to better understand cancer evolution and organism development.

The characterisation of somatic mutations allows the possibility of answering a range of questions. I am particularly interested in understanding how different genomic contexts influence mutation and evolution, and how these effects compare at the somatic (either normal or cancer cells) and germline levels. Also of interest is how mutation signatures can help understand cellular processes like DNA repair and how they relate to environmental exposure. The interplay between genomic context and mutational processes is key to unraveling adaptive evolution (causality) during cancer progression. Somatic mutation is also very promising to help understand embryonic development and the organisation of cells within tissues and organs. This is not only important to understanding cancer progression, but also to query the developmental plan for evolutionary adaptive strategies.

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