Dr Paul Flicek's research focuses on an evolutionary-based understanding of transcriptional regulation and cell-type specificity including the development of computational models for genome annotation. He has played a role in a number of international scientific consortia including the ENCODE project, the International Human Epigenome Consortium (IHEC) and the mouse, chicken, and gibbon genome projects.
Paul has worked with scientists from the Sanger Institute since 2001 on aspects of genome annotation and comparative genomics, initially with sequencing of the mouse genome and more recently across vertebrate evolution. In addition, he works closely with Human Genetics on large-scale projects such as the 1000 Genomes and on the management of data arising from modern genomics research.
Paul graduated from Drake University with a BS (Manga cum laude) in Physics and worked as a health physicist before moving to Washington University in St. Louis, where he completed MSc degrees in both Biomedical Engineering and Computer Science en route to a DSc focused on computational biology. He arrived at EMBL-EBI in 2005 to do postdoctoral research with Ewan Birney, became a member of the EMBL faculty in 2007 and an EMBL Senior Scientist in 2011.
Paul leads the Ensembl project and has stratagic responsibility for the seven faculty groups that deliver EMBL-EBI's resources focused on genes, genomes and variation.