Dr Amy Yeung | Senior Staff Scientist

This person is a member of Sanger Institute Alumni.

Yeung, Amy

My current research involves using hIPSC to develop alternative in vitro models to study host-pathogen interactions. Specifically, I differentiate hIPSCs to macrophages to study its response to pathogens, including Salmonella and Chlamydia. To study the response of the macrophages, I use various techniques, including flow cytometry, cellular imagining (Cellomics, fluroescent microscopy, electron microscopy), RNA sequencing, and proteomics. I am also using the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) gene editing technology to generate genome-wide CRISPR-Cas9 knockout mutant libraries in a human macrophage line to identify identify novel host factors involved in macrophage resistance to pathogens and toxins.

Publications

  • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

    Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W et al.

    Nature communications 2017;8;15013

  • Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

    Yeung AT, Hale C, Xia J, Tate PH, Goulding D et al.

    Scientific reports 2015;5;8908

  • Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

    Hale C, Yeung A, Goulding D, Pickard D, Alasoo K et al.

    PloS one 2015;10;5;e0124307

  • The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa.

    Yeung AT, Bains M and Hancock RE

    Journal of bacteriology 2011;193;4;918-31

  • Antibiotic resistance in Pseudomonas aeruginosa biofilms: towards the development of novel anti-biofilm therapies.

    Taylor PK, Yeung AT and Hancock RE

    Journal of biotechnology 2014;191;121-30

  • Mucin promotes rapid surface motility in Pseudomonas aeruginosa.

    Yeung AT, Parayno A and Hancock RE

    mBio 2012;3;3

  • Multifunctional cationic host defence peptides and their clinical applications.

    Yeung AT, Gellatly SL and Hancock RE

    Cellular and molecular life sciences : CMLS 2011;68;13;2161-76

  • Therapeutic potential of host defense peptides in antibiotic-resistant infections.

    Afacan NJ, Yeung AT, Pena OM and Hancock RE

    Current pharmaceutical design 2012;18;6;807-19

  • Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.

    Yeung AT, Torfs EC, Jamshidi F, Bains M, Wiegand I et al.

    Journal of bacteriology 2009;191;18;5592-602

  • Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.

    Yeung AT, Janot L, Pena OM, Neidig A, Kukavica-Ibrulj I et al.

    Infection and immunity 2014;82;3;1256-67

Yeung, Amy