Nicole is a Postdoctoral Fellow in the Pathogen Genomics group. Her focus is on developing high-throughput computational methods for understanding adaptation in bacterial pathogens. She combines a background in biochemistry and genetics with experience in statistics and machine learning to find new ways to gain insight from genome sequence data.
During my PhD I developed a bioinformatic method which weights mutations in protein coding genes based on their predicted impact on protein function. I then collaborated with a variety of groups to apply this method to the study of the genomic changes that occur during niche adaptation in bacterial pathogens.
My current work is focussed on linking genotype to phenotype in bacterial pathogens using comparative genomics, genome-wide association studies and machine learning. This work is a balance of developing new methods and applying them to questions regarding the evolution of virulence in a range of bacterial species. I am particularly interested in understanding the ways bacteria enter new pathogenic niches, and how they adapt to their new environment. I’ve been applying these insights to the development of ways to recognise emerging pathogens using genome sequence data.