Stephen Watt | Senior Staff Scientist

Watt, Stephen

My main research interests lie in how genetic variation influences transcriptional regulation and gene expression programs.

To fulfil this goal I am currently in the group of Professor Nicole Soranzo. Here we study the effects and consequences of genetic variation on epigenetic and transcriptional regulation at a population level. Using immune cells as our model, I am primarily involved in large scale data acquisition and analysis of ChIP-seq experiments for transcription factors essential to myeloid cell function.


  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

    Chen L, Ge B, Casale FP, Vasquez L, Kwan T et al.

    Cell 2016;167;5;1398-1414.e24

  • AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation.

    Aldridge S, Watt S, Quail MA, Rayner T, Lukk M et al.

    Genome biology 2013;14;11;R124

  • Rapid turnover of long noncoding RNAs and the evolution of gene expression.

    Kutter C, Watt S, Stefflova K, Wilson MD, Goncalves A et al.

    PLoS genetics 2012;8;7;e1002841

  • Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

    Faure AJ, Schmidt D, Watt S, Schwalie PC, Wilson MD et al.

    Genome research 2012;22;11;2163-75

  • A coordinated global control over cellular transcription.

    Zhurinsky J, Leonhard K, Watt S, Marguerat S, Bähler J and Nurse P

    Current biology : CB 2010;20;22;2010-5

  • Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

    Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V et al.

    Nature 2008;453;7199;1239-43

  • urg1: a uracil-regulatable promoter system for fission yeast with short induction and repression times.

    Watt S, Mata J, López-Maury L, Marguerat S, Burns G and Bähler J

    PloS one 2008;3;1;e1428

Career/Research Highlights

Watt, Stephen
Stephen's Timeline

Staff Scientist, Human Complex Traits laboratory, WTSI


Senior Scientific Officer, Regulatory systems biology laboratory, CRUK


Senior Research Assistant, Fission Yeast Functional Genomics Group, WTSI


Research Assistant, Cancer Genome Project, WTSI


Human Genome Project Sequencing team, WTSI


Bsc Biology, University of Paisley