Thierry Voet, PhD | Group leader

Voet, Thierry

Thierry Voet's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable the exploration of DNA-mutation, the genetic differences between cells in a person's body and the relation of this diversity to disease.

We are developing methods to determine all classes of genetic variants in the DNA of a single cell, as well as the RNA molecules the cell transcribes, using next-generation sequencing. We are applying our methods to study mutagenesis (the mechanism and rate of genetic mutation), somatic genetic heterogeneity (the degree of genetic difference between individual cells in a person's body) and their effect on disease. Using our methods, we are probing for the extent, nature and biology of cellular heterogeneity in health and disease.


  • Concurrent whole-genome haplotyping and copy-number profiling of single cells.

    Zamani Esteki M, Dimitriadou E, Mateiu L, Melotte C, Van der Aa N et al.

    American journal of human genetics 2015;96;6;894-912

  • Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations.

    Wilson NK, Kent DG, Buettner F, Shehata M, Macaulay IC et al.

    Cell stem cell 2015;16;6;712-24

  • G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

    Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX et al.

    Nature methods 2015;12;6;519-22

  • SNES makes sense? Single-cell exome sequencing evolves.

    Voet T and Van Loo P

    Genome biology 2015;16;86

  • Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Cooper CS, Eeles R, Wedge DC, Van Loo P, Gundem G et al.

    Nature genetics 2015;47;4;367-372

  • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.

    de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC et al.

    Science (New York, N.Y.) 2014;346;6206;251-6

  • Single cell analysis of cancer genomes.

    Van Loo P and Voet T

    Current opinion in genetics & development 2014;24;82-91

  • Single cell segmental aneuploidy detection is compromised by S phase.

    Dimitriadou E, Van der Aa N, Cheng J, Voet T and Vermeesch JR

    Molecular cytogenetics 2014;7;46

  • Single cell genomics: advances and future perspectives.

    Macaulay IC and Voet T

    PLoS genetics 2014;10;1;e1004126

  • Mosaic copy number variation in human neurons.

    McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T et al.

    Science (New York, N.Y.) 2013;342;6158;632-7

  • Single-cell paired-end genome sequencing reveals structural variation per cell cycle.

    Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J et al.

    Nucleic acids research 2013;41;12;6119-38

  • Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains.

    Van der Aa N, Cheng J, Mateiu L, Zamani Esteki M, Kumar P et al.

    Nucleic acids research 2013;41;6;e66

  • Next-generation sequencing of disseminated tumor cells.

    Møller EK, Kumar P, Voet T, Peterson A, Van Loo P et al.

    Frontiers in oncology 2013;3;320

  • Preimplantation genetic diagnosis guided by single-cell genomics.

    Van der Aa N, Zamani Esteki M, Vermeesch JR and Voet T

    Genome medicine 2013;5;8;71

  • Alzheimer's disease: A protective mutation.

    De Strooper B and Voet T

    Nature 2012;488;7409;38-9

  • Microarray analysis of copy number variation in single cells.

    Konings P, Vanneste E, Jackmaert S, Ampe M, Verbeke G et al.

    Nature protocols 2012;7;2;281-310

  • Single-cell copy number variation detection.

    Cheng J, Vanneste E, Konings P, Voet T, Vermeesch JR and Moreau Y

    Genome biology 2011;12;8;R80

  • Breakage-fusion-bridge cycles leading to inv dup del occur in human cleavage stage embryos.

    Voet T, Vanneste E, Van der Aa N, Melotte C, Jackmaert S et al.

    Human mutation 2011;32;7;783-93

  • The human cleavage stage embryo is a cradle of chromosomal rearrangements.

    Voet T, Vanneste E and Vermeesch JR

    Cytogenetic and genome research 2011;133;2-4;160-8

  • Chromosome instability is common in human cleavage-stage embryos.

    Vanneste E, Voet T, Le Caignec C, Ampe M, Konings P et al.

    Nature medicine 2009;15;5;577-83

Voet, Thierry
Thierry's Timeline

Associate Professor at the University of Leuven (KU Leuven), Leuven, Belgium


Co-founder of the Sanger Institute-EBI Single-Cell Genomics Center


Associate Faculty Member and Group-leader to the Wellcome Trust Sanger Institute (Hinxton-Cambridge, UK)


Visiting researcher in the Cancer Genome Project at the Wellcome Trust Sanger Institute (Hinxton-Cambridge, UK)


Tenure Track docent at the University of Leuven (KU Leuven), Leuven, Belgium


Ph.D. in Medical Sciences (University of Leuven, KU Leuven, Belgium)