Dr Ioanna Tachmazidou | Staff Scientist

This person is a member of Sanger Institute Alumni.

Tachmazidou, Ioanna

My research interests are on all aspects of statistical genetics, and in particular in the genetic etiology of common disease. My current work is primarily focused on analyzing whole genome sequence data for metabolic related traits, as well as developing statistical methodology and software for the discovery of disease susceptibility loci. My research interests include: fine-scale mapping, design and analysis of sequence studies and rare variants analysis, multivariate analysis of sequence data, Bayesian survival analysis, Bayesian inference and model selection.

I am involved in a number of international consortia, including the AGVP, UK10K, SCOOP, HELIC, and the INCHARGE projects.

Publications

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • The African Genome Variation Project shapes medical genetics in Africa.

    Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I et al.

    Nature 2015;517;7534;327-32

  • A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

    Tachmazidou I, Dedoussis G, Southam L, Farmaki AE, Ritchie GR et al.

    Nature communications 2013;4;2872

  • Estimating genome-wide significance for whole-genome sequencing studies.

    Xu C, Tachmazidou I, Walter K, Ciampi A, Zeggini E et al.

    Genetic epidemiology 2014;38;4;281-90

  • Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

    Huckins LM, Boraska V, Franklin CS, Floyd JA, Southam L et al.

    European journal of human genetics : EJHG 2014;22;10;1190-200

  • In search of low-frequency and rare variants affecting complex traits.

    Panoutsopoulou K, Tachmazidou I and Zeggini E

    Human molecular genetics 2013;22;R1;R16-21

  • Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI.

    Vimaleswaran KS, Tachmazidou I, Zhao JH, Hirschhorn JN, Dudbridge F and Loos RJ

    Human molecular genetics 2012;21;20;4537-42

  • Rare variant association testing for next-generation sequencing data via hierarchical clustering.

    Tachmazidou I, Morris A and Zeggini E

    Human heredity 2012;74;3-4;165-71

  • Bayesian variable selection for survival regression in genetics.

    Tachmazidou I, Johnson MR and De Iorio M

    Genetic epidemiology 2010;34;7;689-701

  • Bayesian survival analysis in genetic association studies.

    Tachmazidou I, Andrew T, Verzilli CJ, Johnson MR and De Iorio M

    Bioinformatics (Oxford, England) 2008;24;18;2030-6

  • Genetic association mapping via evolution-based clustering of haplotypes.

    Tachmazidou I, Verzilli CJ and De Iorio M

    PLoS genetics 2007;3;7;e111

  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

    Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF et al.

    PLoS genetics 2015;11;10;e1005378

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Height-reducing variants and selection for short stature in Sardinia.

    Zoledziewska M, Sidore C, Chiang CW, Sanna S, Mulas A et al.

    Nature genetics 2015

  • The African Genome Variation Project shapes medical genetics in Africa.

    Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I et al.

    Nature 2015;517;7534;327-32

  • Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

    Panoutsopoulou K, Hatzikotoulas K, Xifara DK, Colonna V, Farmaki AE et al.

    Nature communications 2014;5;5345

  • Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

    Huckins LM, Boraska V, Franklin CS, Floyd JA, Southam L et al.

    European journal of human genetics : EJHG 2014;22;10;1190-200

  • A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

    Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G et al.

    Nature communications 2014;5;4871

  • Estimating genome-wide significance for whole-genome sequencing studies.

    Xu C, Tachmazidou I, Walter K, Ciampi A, Zeggini E et al.

    Genetic epidemiology 2014;38;4;281-90

  • A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.

    Speed D, Hoggart C, Petrovski S, Tachmazidou I, Coffey A et al.

    Human molecular genetics 2014;23;1;247-58

  • In search of low-frequency and rare variants affecting complex traits.

    Panoutsopoulou K, Tachmazidou I and Zeggini E

    Human molecular genetics 2013;22;R1;R16-21

  • A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

    Tachmazidou I, Dedoussis G, Southam L, Farmaki AE, Ritchie GR et al.

    Nature communications 2013;4;2872

  • Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI.

    Vimaleswaran KS, Tachmazidou I, Zhao JH, Hirschhorn JN, Dudbridge F and Loos RJ

    Human molecular genetics 2012;21;20;4537-42

  • Rare variant association testing for next-generation sequencing data via hierarchical clustering.

    Tachmazidou I, Morris A and Zeggini E

    Human heredity 2012;74;3-4;165-71

  • Bayesian semiparametric meta-analysis for genetic association studies.

    De Iorio M, Newcombe PJ, Tachmazidou I, Verzilli CJ and Whittaker JC

    Genetic epidemiology 2011;35;5;333-40

  • Bayesian variable selection for survival regression in genetics.

    Tachmazidou I, Johnson MR and De Iorio M

    Genetic epidemiology 2010;34;7;689-701

  • Bayesian survival analysis in genetic association studies.

    Tachmazidou I, Andrew T, Verzilli CJ, Johnson MR and De Iorio M

    Bioinformatics (Oxford, England) 2008;24;18;2030-6

Tachmazidou, Ioanna
Ioanna's Timeline
2011

Staff Scientist, Wellcome Trust Sanger Institute

2008

Career Development Fellow in Statistical Genetics, Medical Research Council, Biostatistics Unit, Cambridge

PhD in Statistical Genetics, Wellcome Trust 4-year PhD program, Imperial College, London

2004

MSc in Bioinformatics, Imperial College, London

2003

MSc in Statistics, University College, London

2002

BSc in Mathematics, Aristotle University of Thessaloniki, Greece