Dr Jawahar Swaminathan | Senior Scientific Manager (DECIPHER Project Manager)

This person is a member of Sanger Institute Alumni.

Swaminathan, Jawahar

I am the Project Manager for the DECIPHER Database and Consortium developed and based at the Wellcome Trust Sanger Institute. As Project Manager for this challenging and medically critical resource, I oversee the day-to-day management of the website, take part in outreach activities and am involved in the planning, implementation and delivery of new developments in DECIPHER.

Prior to joining the WTSI, I worked at the European Bioinformatics Institute as the Head of Annotation for the Protein Data Bank in Europe (PDBe) where I led a team of annotation specialists taking care of structures deposited to the PDB. I was involved in outreach activities for the PDBe and have travelled extensively speaking at various scientific conferences and meetings and conducted teaching courses. As a researcher at the University of Bath, I have worked on a MRC funded programme grant on proteins involved in inflammatory processes and have determined the 3-dimensional structures of many proteins involved in allergy and asthma. I have also developed BioBar, a browser bioinformatics search add-on for Firefox.

I retain a keen interest in structural biology and protein structure modelling.

Publications

  • Facilitating collaboration in rare genetic disorders through effective matchmaking in DECIPHER.

    Chatzimichali EA, Brent S, Hutton B, Perrett D, Wright CF et al.

    Human mutation 2015;36;10;941-9

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • PDBe: Protein Data Bank in Europe.

    Velankar S, Alhroub Y, Best C, Caboche S, Conroy MJ et al.

    Nucleic acids research 2012;40;Database issue;D445-52

  • Eosinophil-granule major basic protein, a C-type lectin, binds heparin.

    Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ and Acharya KR

    Biochemistry 2005;44;43;14152-8

  • Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.

    Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC et al.

    Structure (London, England : 1993) 2003;11;5;521-32

  • Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin.

    Swaminathan GJ, Holloway DE, Veluraja K and Acharya KR

    Biochemistry 2002;41;10;3341-52

  • Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.

    Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD et al.

    The Journal of biological chemistry 2001;276;28;26197-203

  • Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.

    Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ and Acharya KR

    Biochemistry 1999;38;42;13837-43

  • Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.

    Akawi N, McRae J, Ansari M, Balasubramanian M, Blyth M et al.

    Nature genetics 2015;47;11;1363-9

  • The Matchmaker Exchange: a platform for rare disease gene discovery.

    Philippakis AA, Azzariti DR, Beltran S, Brookes AJ, Brownstein CA et al.

    Human mutation 2015;36;10;915-21

  • Facilitating collaboration in rare genetic disorders through effective matchmaking in DECIPHER.

    Chatzimichali EA, Brent S, Hutton B, Perrett D, Wright CF et al.

    Human mutation 2015;36;10;941-9

  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • Rare variants in NR2F2 cause congenital heart defects in humans.

    Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP et al.

    American journal of human genetics 2014;94;4;574-85

  • DECIPHER: database for the interpretation of phenotype-linked plausibly pathogenic sequence and copy-number variation.

    Bragin E, Chatzimichali EA, Wright CF, Hurles ME, Firth HV et al.

    Nucleic acids research 2014;42;Database issue;D993-D1000

  • DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.

    Swaminathan GJ, Bragin E, Chatzimichali EA, Corpas M, Bevan AP et al.

    Human molecular genetics 2012;21;R1;R37-44

  • PDBe: Protein Data Bank in Europe.

    Velankar S, Alhroub Y, Best C, Caboche S, Conroy MJ et al.

    Nucleic acids research 2012;40;Database issue;D445-52

  • Straightforward and complete deposition of NMR data to the PDBe.

    Penkett CJ, van Ginkel G, Velankar S, Swaminathan J, Ulrich EL et al.

    Journal of biomolecular NMR 2010;48;2;85-92

  • Data deposition and annotation at the worldwide protein data bank.

    Dutta S, Burkhardt K, Young J, Swaminathan GJ, Matsuura T et al.

    Molecular biotechnology 2009;42;1;1-13

  • Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.

    Baker MD, Holloway DE, Swaminathan GJ and Acharya KR

    Biochemistry 2006;45;2;416-26

  • E-MSD: improving data deposition and structure quality.

    Tagari M, Tate J, Swaminathan GJ, Newman R, Naim A et al.

    Nucleic acids research 2006;34;Database issue;D287-90

  • Eosinophil-granule major basic protein, a C-type lectin, binds heparin.

    Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ and Acharya KR

    Biochemistry 2005;44;43;14152-8

  • E-MSD: an integrated data resource for bioinformatics.

    Golovin A, Oldfield TJ, Tate JG, Velankar S, Barton GJ et al.

    Nucleic acids research 2004;32;Database issue;D211-6

  • Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity.

    Zhang Y, Swaminathan GJ, Deshpande A, Boix E, Natesh R et al.

    Biochemistry 2003;42;46;13512-21

  • Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.

    Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC et al.

    Structure (London, England : 1993) 2003;11;5;521-32

  • E-MSD: the European Bioinformatics Institute Macromolecular Structure Database.

    Boutselakis H, Dimitropoulos D, Fillon J, Golovin A, Henrick K et al.

    Nucleic acids research 2003;31;1;458-62

  • Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase.

    Boix E, Zhang Y, Swaminathan GJ, Brew K and Acharya KR

    The Journal of biological chemistry 2002;277;31;28310-8

  • Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.

    Ackerman SJ, Liu L, Kwatia MA, Savage MP, Leonidas DD et al.

    The Journal of biological chemistry 2002;277;17;14859-68

  • Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin.

    Swaminathan GJ, Holloway DE, Veluraja K and Acharya KR

    Biochemistry 2002;41;10;3341-52

  • Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus.

    Boix E, Swaminathan GJ, Zhang Y, Natesh R, Brew K and Acharya KR

    The Journal of biological chemistry 2001;276;51;48608-14

  • Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution.

    Jain D, Nair DT, Swaminathan GJ, Abraham EG, Nagaraju J and Salunke DM

    The Journal of biological chemistry 2001;276;44;41377-82

  • Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.

    Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD et al.

    The Journal of biological chemistry 2001;276;28;26197-203

  • Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.

    Leonidas DD, Boix E, Prill R, Suzuki M, Turton R et al.

    The Journal of biological chemistry 2001;276;18;15009-17

  • The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.

    Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M et al.

    The Journal of biological chemistry 2001;276;15;12153-61

  • Selective Recognition of Mannose by the Human Eosinophil Charcot-Leyden Crystal Protein (Galectin-10): A Crystallographic Study at 1.8 Å Resolution.

    Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ and Acharya KR

    Biochemistry 1999;38;46;15406

  • Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.

    Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ and Acharya KR

    Biochemistry 1999;38;42;13837-43

Swaminathan, Jawahar
Jawahar's Timeline
2012

Started at Wellcome Trust Sanger Institute as DECIPHER Project Manager

2005

Head of Annotation and Deposition, Protein Databank in Europe, EBI, Cambridge

2001

Joined European Bioinformatics Institute, Cambridge as Annotation Specialist, Protein Data Bank in Europe

1997

PostDoctoral Research Officer, University of Bath, UK

Awarded PhD in Structural Biology, National Institute of Immunology, New Delhi, India

1992

Awarded MSc in Biotechnology, IIT Roorkee, India

1990

Awarded BSc in Life Sciences, University of Lucknow, India