After gaining experience in experimental biochemistry/cellular biology, I joined the Wellcome Trust Sanger Institute as a senior bioinformatician. I am especially interested in big-data driven research fueled by next generation sequencing techniques. These advances in genomics are changing the way we understand basic biological processes, and leading to significant progress in treatment of complex diseases. It is thrilling experience to be part of this revolution in a world leading institution. As a bioinformatician at the Zeggini group I contribute to various genome wide association studies by utilizing my computational skills and deep understanding of biological processes.
Charged single alpha-helix: a versatile protein structural motif.
An unstable head-rod junction may promote folding into the compact off-state conformation of regulated myosins.
Journal of molecular biology 2008;375;5;1434-43
Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome.
PloS one 2011;6;4;e18818
Charged single alpha-helices in proteomes revealed by a consensus prediction approach.
Biochimica et biophysica acta 2012;1824;4;637-46
Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.
The Journal of biological chemistry 2010;285;49;38649-57
Folded-unfolded cross-predictions and protein evolution: the case study of coiled-coils.
FEBS letters 2010;584;8;1623-7