Ms Loz Southam | Senior Staff Scientist

This person is a member of Sanger Institute Alumni.

Southam, Loz

Loz Southam is a Senior Staff Scientist at the Wellcome Trust Sanger Institute where she aims to identify novel genetic variants that are associated with complex disease. Loz focuses on isolated populations in order to help discover rare and low frequency genetic variants that predispose individuals to common cardiometabolic diseases.


  • Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

    Huckins LM, Boraska V, Franklin CS, Floyd JA, Southam L et al.

    European journal of human genetics : EJHG 2014;22;10;1190-200

  • A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

    Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G et al.

    Nature communications 2014;5;4871

  • Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

    Panoutsopoulou K, Hatzikotoulas K, Xifara DK, Colonna V, Farmaki AE et al.

    Nature communications 2014;5;5345

  • Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study.

    Ntalla I, Panoutsopoulou K, Vlachou P, Southam L, William Rayner N et al.

    Annals of human genetics 2013;77;3;268-74

  • A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

    Tachmazidou I, Dedoussis G, Southam L, Farmaki AE, Ritchie GR et al.

    Nature communications 2013;4;2872

  • Genome-wide meta-analysis of common variant differences between men and women.

    Boraska V, Jerončić A, Colonna V, Southam L, Nyholt DR et al.

    Human molecular genetics 2012;21;21;4805-15

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

    arcOGEN Consortium, arcOGEN Collaborators, Zeggini E, Panoutsopoulou K, Southam L et al.

    Lancet (London, England) 2012;380;9844;815-23

  • A variant in MCF2L is associated with osteoarthritis.

    Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T et al.

    American journal of human genetics 2011;89;3;446-50

  • Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.

    Wilkins JM, Southam L, Mustafa Z, Chapman K and Loughlin J

    BMC medical genetics 2009;10;141

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Loz's Timeline

Senior Staff Scientist, Wellcome Trust Sanger Institute


Research Assistant, University of Oxford, Botnar Research Centre, Oxford, UK


Research Assistant, University of Oxford, Institute of Molecular Medicine, Oxford, UK


Scientific Officer, Medical Research Council, Harwell, Didcot, Oxford, UK


Research Assistant, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

First-class BSc (hons) degree in Biomedical Sciences, Bradford University, UK.