Blagoje is a Postdoc at Gosia Trynka’s group. He uses high-throughput technologies to investigate the impact of genetic variation on T cell function.
Throughout my education I have been fascinated by the complexity of the mechanisms that control our immune system. This led me to undertake my PhD training with Prof. David Sansom at UCL, where I gained a valuable understanding of the cell biology behind the control of T cell activation. During those years I realised that the processes that control immune reactions are highly variable and that understanding their genetic control could generate tremendous insight into the development of diseases. Motivated by this, I decided to research the genetic control of T cell activation. During my postdoctoral training in Dr Gosia Trynka’s group, I bridged functional immunology with genomic tools in order to take the next steps in understanding how genetic variants lead to complex immune diseases and how to identify new drug targets. I focused on generating large scale data on different immune cell types and states and developing statistical methods that enable the translation of genetic variants into immune functions.
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.
Nature genetics 2019;51;10;1486-1493
Immunogenomic approaches to understand the function of immune disease variants.
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Scientific reports 2017;7;1;7652
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
Journal of immunology (Baltimore, Md. : 1950) 2017;198;1;528-537