Dr Miriam Smith | Staff Scientist

This person is a member of Sanger Institute Alumni.

Smith, Miriam

Miriam is a Staff Scientist within the Development side of the DNA Pipelines Research and Development team. Miriam is involved in developing protocols and procedures that can be used directly by the operational teams and she works proactively to rectify any sequencing quality problems flagged by core facilities. Miriam is also involved in tesing new products, particularly novel library preparation methodologies.

As a Staff Scientist within the Development side of the DNA Pipelines Research and Development Team I have to work proactively with the operational team members to improve their processes and ensure the pipelines are working efficiently. I am involved in troubleshooting current processes with the aim of making them cheaper, quicker and more accurate. I am also involved in testing new processes and protocols that could revolutionise the operational pipelines and keep them at the cutting edge of the scientific field. This includes new robotics, library preparation methodologies and library QC processes.

In 2013 the DNA Pipelines Research and Development Team underwent some restructuring to form two overlapping teams (Research and Development teams), of which I became a member of the Development team. Prior to this, as a member of a more broad reaching Sequencing Research and Development Team, I was involved in many more research based activities including running the Ion Torrent sequencing machines and developing enrichment proceses for targeted sequencing. I became a Staff Scientist in 2011, after joining the institute as a Post-doctoral Researcher in 2009.


  • G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

    Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX et al.

    Nature methods 2015;12;6;519-22

  • SASI-Seq: sample assurance Spike-Ins, and highly differentiating 384 barcoding for Illumina sequencing.

    Quail MA, Smith M, Jackson D, Leonard S, Skelly T et al.

    BMC genomics 2014;15;110

  • A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers.

    Quail MA, Smith M, Coupland P, Otto TD, Harris SR et al.

    BMC genomics 2012;13;341

  • An In-Solution Hybridisation Method for the Isolation of Pathogen DNA from Human DNA-rich Clinical Samples for Analysis by NGS.

    Smith M, Campino S, Gu Y, Clark TG, Otto TD et al.

    The open genomics journal 2012;5

  • Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk.

    Barber ME, Save V, Carneiro F, Dwerryhouse S, Lao-Sirieix P et al.

    The Journal of pathology 2008;216;3;286-94

  • Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer.

    Barber M, Murrell A, Ito Y, Maia AT, Hyland S et al.

    The Journal of pathology 2008;216;3;295-306

Smith, Miriam
Miriam's Timeline

Became a development specialist within the DNA Pipelines Research and Development Team


Became a Staff Scientist in the Sequencing Research and Development Team


Started work at the Wellcome Sanger Institute as a Post-doctoral Scientist


Obtained PhD in Oncolcogy from the University of Cambridge