Carol Smee | Regulatory Compliance Manager

Smee, Carol

The Ethics and Governance Office (EGO) includes myself, Joanne Doleman (Research Governance Manager), George Martin (Research Governance Officer), Catherine McCarthy (Compliance Officer - Nagoya Protocol) and Jessica Rowbotham (Internal Audit Apprentice). We are responsible for advising members of Sanger Institute staff about compliance with the Human Tissue Act, Animals (Scientific Procedures) Act, the Nagoya Protocol and associated Institute policies. We help achieve compliance through the initiation, administration and development of internal processes, audit and monitoring, and communicate regulatory and policy requirements using a variety of means, including team talks, induction and training sessions, and face-to-face meetings.

We lead on consultation responses for the Institute where national or international proposals for changes to relevant research legislation may impact on our research, or where we wish to join the debate on ethical research practice.

Outside Activities

Health Research Authority Trainer on the Human Tissue Act and Course Lead for 'Genetic and Genomic Research - What RECs Should Consider'

Member of EMBL Bioethical Internal Advisory Committee (BIAC)


  • 'Pop-Up' Governance: developing internal governance frameworks for consortia: the example of UK10K.

    Kaye J, Muddyman D, Smee C, Kennedy K, Bell J and UK10K

    Life sciences, society and policy 2015;11;10

  • Sharing and Reuse of Sensitive Data and Samples: Supporting Researchers in Identifying Ethical and Legal Requirements.

    Sariyar M, Schluender I, Smee C and Suhr S

    Biopreservation and biobanking 2015;13;4;263-70

  • Managing clinically significant findings in research: the UK10K example.

    Kaye J, Hurles M, Griffin H, Grewal J, Bobrow M et al.

    European journal of human genetics : EJHG 2014;22;9;1100-4

  • Implementing a successful data-management framework: the UK10K managed access model.

    Muddyman D, Smee C, Griffin H and Kaye J

    Genome medicine 2013;5;11;100

  • Baculovirus expression vector system: an emerging host for high-throughput eukaryotic protein expression.

    Shrestha B, Smee C and Gileadi O

    Methods in molecular biology (Clifton, N.J.) 2008;439;269-89

  • High throughput production of recombinant human proteins for crystallography.

    Gileadi O, Burgess-Brown NA, Colebrook SM, Berridge G, Savitsky P et al.

    Methods in molecular biology (Clifton, N.J.) 2008;426;221-46

  • Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.

    Stokes NR, Thomaides-Brears HB, Barker S, Bennett JM, Berry J et al.

    Antimicrobial agents and chemotherapy 2013;57;12;5977-86

  • DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.

    East SP, White CB, Barker O, Barker S, Bennett J et al.

    Bioorganic & medicinal chemistry letters 2009;19;3;894-9

Smee, Carol
Carol's Timeline

Regulatory Compliance Manager, Wellcome Sanger Institute


Regulatory Adviser, Wellcome Trust Sanger Institute


Senior Scientist, Prolysis Ltd., Oxford


Research Assistant, Structural Genomics Consortium, Oxford


Education and Outreach Officer, Brewhouse Theatre and Arts Centre, Taunton


Chief Microbiology Technician, University of West of England


Senior Microbiology Technician, University of West of England


Fermentation Technician, University of East Anglia


Research and Development Technician, Continental Wine Experts Ltd., Norfolk


Education Officer with the National Trust (Dunwich Heath Nature Reserve) and River Inspector (Broads Authority, Norfolk Broads)


Microbiology Researcher, University of Luton


Secondary School and Sixth Form Teacher (Biology/Chemistry)