Dr Ed Ryder | Senior Scientific Manager, Mouse Molecular Technologies

This person is a member of Sanger Institute Alumni.

Ryder, Ed

I am a specialist in the operational side of basic research, developing small molecular biology pilot projects and scaling them up for the requirements of high-throughput international collaborations.

My personal research interests are in developing methods to facilitate the various projects we are involved in and working with academic research groups that use our systems to answer hypothesis-driven questions about genetic diseases and development.

Responsible for the Mouse Molecular Technologies team within Mouse Pipelines, characterising and genotyping new knockout strains of mice for international collaborations and the scientific community at large.

Publications

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    de Angelis MH, Nicholson G, Selloum M, White J, Morgan H et al.

    Nature genetics 2015;47;9;969-978

  • Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library.

    Lowe N, Rees JS, Roote J, Ryder E, Armean IM et al.

    Development (Cambridge, England) 2014;141;20;3994-4005

  • Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase.

    Ryder E, Doe B, Gleeson D, Houghton R, Dalvi P et al.

    Transgenic research 2014;23;1;177-85

  • Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

    Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2013;24;7-8;286-94

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • The mammalian gene function resource: the International Knockout Mouse Consortium.

    Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;580-6

  • The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource.

    Ryder E, Ashburner M, Bautista-Llacer R, Drummond J, Webster J et al.

    Genetics 2007;177;1;615-29

  • The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.

    Ryder E, Blows F, Ashburner M, Bautista-Llacer R, Coulson D et al.

    Genetics 2004;167;2;797-813

  • Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

    van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H et al.

    Nature 2017;541;7636;233-236

  • High-throughput discovery of novel developmental phenotypes.

    Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD et al.

    Nature 2016;537;7621;508-514

  • Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

    van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H et al.

    Nature 2017;541;7636;233-236

  • High-throughput discovery of novel developmental phenotypes.

    Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD et al.

    Nature 2016;537;7621;508-514

  • Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

    Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D et al.

    The Journal of pathology 2016;239;3;374-83

  • Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration.

    Joyce PI, Fratta P, Landman AS, Mcgoldrick P, Wackerhage H et al.

    Human molecular genetics 2016;25;2;291-307

  • Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.

    Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D et al.

    Transgenic research 2015;24;5;921-7

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    de Angelis MH, Nicholson G, Selloum M, White J, Morgan H et al.

    Nature genetics 2015;47;9;969-978

  • Deubiquitinase MYSM1 Is Essential for Normal Fetal Liver Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow.

    Förster M, Belle JI, Petrov JC, Ryder EJ, Clare S and Nijnik A

    Stem cells and development 2015;24;16;1865-77

  • Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library.

    Lowe N, Rees JS, Roote J, Ryder E, Armean IM et al.

    Development (Cambridge, England) 2014;141;20;3994-4005

  • Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase.

    Ryder E, Doe B, Gleeson D, Houghton R, Dalvi P et al.

    Transgenic research 2014;23;1;177-85

  • Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

    Maguire S, Estabel J, Ingham N, Pearson S, Ryder E et al.

    PloS one 2014;9;3;e91807

  • Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

    Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2013;24;7-8;286-94

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M et al.

    Cell 2013;154;2;452-64

  • Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

    Ryder E, Wong K, Gleeson D, Keane TM, Sethi D et al.

    Genesis (New York, N.Y. : 2000) 2013;51;7;523-8

  • Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

    Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H et al.

    American journal of human genetics 2012;91;6;998-1010

  • Large-scale mouse knockouts and phenotypes.

    Ramírez-Solis R, Ryder E, Houghton R, White JK and Bottomley J

    Wiley interdisciplinary reviews. Systems biology and medicine 2012;4;6;547-63

  • The mammalian gene function resource: the International Knockout Mouse Consortium.

    Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;580-6

  • Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

    Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H et al.

    Mammalian genome : official journal of the International Mammalian Genome Society 2012;23;9-10;600-10

  • The role of sphingosine-1-phosphate transporter Spns2 in immune system function.

    Nijnik A, Clare S, Hale C, Chen J, Raisen C et al.

    Journal of immunology (Baltimore, Md. : 1950) 2012;189;1;102-11

  • Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

    Bassett JH, Gogakos A, White JK, Evans H, Jacques RM et al.

    PLoS genetics 2012;8;8;e1002858

  • In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry.

    Rees JS, Lowe N, Armean IM, Roote J, Johnson G et al.

    Molecular & cellular proteomics : MCP 2011;10;6;M110.002386

  • Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.

    Malzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE et al.

    Journal of cell science 2010;123;Pt 17;2892-900

  • Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease.

    Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E et al.

    The European journal of neuroscience 2009;29;7;1335-47

  • The Flannotator--a gene and protein expression annotation tool for Drosophila melanogaster.

    Ryder E, Spriggs H, Drummond E, St Johnston D and Russell S

    Bioinformatics (Oxford, England) 2009;25;4;548-9

  • The evolution of the DLK1-DIO3 imprinted domain in mammals.

    Edwards CA, Mungall AJ, Matthews L, Ryder E, Gray DJ et al.

    PLoS biology 2008;6;6;e135

  • The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource.

    Ryder E, Ashburner M, Bautista-Llacer R, Drummond J, Webster J et al.

    Genetics 2007;177;1;615-29

  • Canine RPGRIP1 mutation establishes cone-rod dystrophy in miniature longhaired dachshunds as a homologue of human Leber congenital amaurosis.

    Mellersh CS, Boursnell ME, Pettitt L, Ryder EJ, Holmes NG et al.

    Genomics 2006;88;3;293-301

  • MAMMOT--a set of tools for the design, management and visualization of genomic tiling arrays.

    Ryder E, Jackson R, Ferguson-Smith A and Russell S

    Bioinformatics (Oxford, England) 2006;22;7;883-4

  • The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.

    Ryder E, Blows F, Ashburner M, Bautista-Llacer R, Coulson D et al.

    Genetics 2004;167;2;797-813

  • Transposable elements as tools for genomics and genetics in Drosophila.

    Ryder E and Russell S

    Briefings in functional genomics & proteomics 2003;2;1;57-71

  • Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes.

    Breen M, Jouquand S, Renier C, Mellersh CS, Hitte C et al.

    Genome research 2001;11;10;1784-95

  • Seven new linkage groups assigned to the DogMap reference families.

    Ryder EJ, Holmes NG, Suter N, Sampson J, Dolf G et al.

    Animal genetics 1999;30;1;63-5

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Ed's Timeline
2008

Wellcome Trust Sanger Institute

2000

Department of Genetics, University of Cambridge

1995

Animal Health Trust