Professor Wolf Reik, FRS, FMedSci | Associate Faculty

Reik, Wolf

Wolf Reik is interested in epigenetic gene regulation in mammalian development. His current research focuses on epigenetic heterogeneity in development and ageing, making use of single cell genomics. He is a founding member of the Single Cell Genomics Centre since 2013.

Wolf obtained his MD from the University of Hamburg, and was an EMBO and Lister Institute Fellow in Cambridge, before becoming Head of the Epigenetics Programme and Associate Director at the Babraham Institute. He is also honorary Professor of Epigenetics at the University of Cambridge. Wolf is an EMBO and Academia Europaea member, and a Fellow of the Royal Society and the Academy of Medical Sciences.


  • Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

    von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A et al.

    Molecular cell 2016;62;6;848-861

  • Maternal DNA Methylation Regulates Early Trophoblast Development.

    Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M et al.

    Developmental cell 2016;36;2;152-63

  • Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.

    Angermueller C, Clark SJ, Lee HJ, Macaulay IC, Teng MJ et al.

    Nature methods 2016;13;3;229-232

  • Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity.

    Smallwood SA, Lee HJ, Angermueller C, Krueger F, Saadeh H et al.

    Nature methods 2014;11;8;817-820

  • FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

    Ficz G, Hore TA, Santos F, Lee HJ, Dean W et al.

    Cell stem cell 2013;13;3;351-9

  • The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.

    Seisenberger S, Andrews S, Krueger F, Arand J, Walter J et al.

    Molecular cell 2012;48;6;849-62

  • Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

    Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F et al.

    Science (New York, N.Y.) 2012;336;6083;934-7

  • The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.

    Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L et al.

    Nature cell biology 2012;14;7;659-65

  • Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

    Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F et al.

    Nature 2011;473;7347;398-402

  • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

    Popp C, Dean W, Feng S, Cokus SJ, Andrews S et al.

    Nature 2010;463;7284;1101-5

  • Defective germline reprogramming rewires the spermatogonial transcriptome.

    Vasiliauskaitė L, Berrens RV, Ivanova I, Carrieri C, Reik W et al.

    Nature structural & molecular biology 2018;25;5;394-404

  • Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.

    Eckersley-Maslin MA, Alda-Catalinas C and Reik W

    Nature reviews. Molecular cell biology 2018

  • Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.

    Olova N, Krueger F, Andrews S, Oxley D, Berrens RV et al.

    Genome biology 2018;19;1;33

Reik, Wolf
Wolf's Timeline

BBSRC Great British Bioscience Pioneer

Thomson Reuters Highly Cited Researcher

Nobel Forum Karolinska Research Lecture


Associate Faculty, Wellcome Trust Sanger Institute

Elected Member of the Academia Europaea


Elected Fellow of the Royal Society


Honorary Professor of Epigenetics, University of Cambridge


Associate Director, Babraham Institute, Cambridge


Elected Fellow of the Academy of Medical Sciences

Elected Member of EMBO


Wellcome Trust Prize in Physiology


Member Lister Institute of Preventive Medicine


Principal Investigator, Babraham Institute, Cambridge


Fellowship of the Lister Institute of Preventive Medicine


EMBO Postdoctoral Fellow at AFRC Animal Research Station, Cambridge

MD University of Hamburg Medical School, Germany