Wolf Reik is interested in epigenetic gene regulation in mammalian development. His current research focuses on epigenetic heterogeneity in development and ageing, making use of single cell genomics. He is a founding member of the Single Cell Genomics Centre since 2013.
Wolf obtained his MD from the University of Hamburg, and was an EMBO and Lister Institute Fellow in Cambridge, before becoming Head of the Epigenetics Programme and Associate Director at the Babraham Institute. He is also honorary Professor of Epigenetics at the University of Cambridge. Wolf is an EMBO and Academia Europaea member, and a Fellow of the Royal Society and the Academy of Medical Sciences.
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Molecular cell 2016;62;6;848-861
Maternal DNA Methylation Regulates Early Trophoblast Development.
Developmental cell 2016;36;2;152-63
Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.
Nature methods 2016;13;3;229-232
Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity.
Nature methods 2014;11;8;817-820
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.
Cell stem cell 2013;13;3;351-9
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.
Molecular cell 2012;48;6;849-62
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.
Science (New York, N.Y.) 2012;336;6083;934-7
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.
Nature cell biology 2012;14;7;659-65
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.
Defective germline reprogramming rewires the spermatogonial transcriptome.
Nature structural & molecular biology 2018;25;5;394-404
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition.
Nature reviews. Molecular cell biology 2018
Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
Genome biology 2018;19;1;33