Bram Prins | Statistical Geneticist

This person is a member of Sanger Institute Alumni.

Prins, Bram

Bram is a statistical geneticist interested in using and eventually developing statistical genetics and bioinformatics approaches to unravel biological mechanisms underlying complex diseases, with a focus on inflammatory and cardiometabolic phenotypes. He is a member of the Analytical Genomics of Complex Traits group at the Wellcome Trust Sanger Institute.

The central theme in my current work is unlocking the mechanisms by which human genetic variation influences complex traits and predisposes to disease.

I use various types of large-scale genetic datasets, ranging from ordinary exome and GWAS chip data, to whole genome sequences to uncover rare and common variation underlying various polygenic traits and diseases and leverage this knowledge to understand comorbidity between diseases. Most of my work is done in the context of large-scale consortia, for which I am involved several efforts of the CHARGE consortium, Spirometa, UKBiLEVE, ICBP, MAGIC, DIAMANTE and YGEN.

Publications

  • In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons.

    Vaez A, Jansen R, Prins BP, Hottenga JJ, de Geus EJ et al.

    Circulation. Cardiovascular genetics 2015;8;3;487-97

  • Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

    Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E et al.

    Cardiovascular research 2015;106;3;520-9

  • Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

    Magnani JW, Brody JA, Prins BP, Arking DE, Lin H et al.

    Circulation. Cardiovascular genetics 2014;7;3;365-73

  • QCGWAS: A flexible R package for automated quality control of genome-wide association results.

    van der Most PJ, Vaez A, Prins BP, Munoz ML, Snieder H et al.

    Bioinformatics (Oxford, England) 2014;30;8;1185-1186

  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

    Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M et al.

    American journal of human genetics 2012;91;4;744-53

  • Genetics of coronary artery disease: genome-wide association studies and beyond.

    Prins BP, Lagou V, Asselbergs FW, Snieder H and Fu J

    Atherosclerosis 2012;225;1;1-10

  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

    Chambers JC, Zhang W, Sehmi J, Li X, Wass MN et al.

    Nature genetics 2011;43;11;1131-8

  • Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.

    Wang X, Prins BP, Sõber S, Laan M and Snieder H

    Current hypertension reports 2011;13;6;442-51

  • Poor replication of candidate genes for major depressive disorder using genome-wide association data.

    Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P et al.

    Molecular psychiatry 2011;16;5;516-32

  • Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells.

    Li Z, Wang L, Zhang W, Fu Y, Zhao H et al.

    Biochemical and biophysical research communications 2007;363;1;165-70

  • Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway.

    Fu Y, Fang Z, Liang Y, Zhu X, Prins P et al.

    Journal of cellular biochemistry 2007;102;3;704-18

  • Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

    Prins BP, Abbasi A, Wong A, Vaez A, Nolte I et al.

    PLoS medicine 2016;13;6;e1001976

  • In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons.

    Vaez A, Jansen R, Prins BP, Hottenga JJ, de Geus EJ et al.

    Circulation. Cardiovascular genetics 2015;8;3;487-97

  • Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

    Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E et al.

    Cardiovascular research 2015;106;3;520-9

  • Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

    Magnani JW, Brody JA, Prins BP, Arking DE, Lin H et al.

    Circulation. Cardiovascular genetics 2014;7;3;365-73

  • QCGWAS: A flexible R package for automated quality control of genome-wide association results.

    van der Most PJ, Vaez A, Prins BP, Munoz ML, Snieder H et al.

    Bioinformatics (Oxford, England) 2014;30;8;1185-1186

  • Genetics of coronary artery disease: genome-wide association studies and beyond.

    Prins BP, Lagou V, Asselbergs FW, Snieder H and Fu J

    Atherosclerosis 2012;225;1;1-10

  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

    Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M et al.

    American journal of human genetics 2012;91;4;744-53

  • Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.

    Wang X, Prins BP, Sõber S, Laan M and Snieder H

    Current hypertension reports 2011;13;6;442-51

  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

    Chambers JC, Zhang W, Sehmi J, Li X, Wass MN et al.

    Nature genetics 2011;43;11;1131-8

  • Poor replication of candidate genes for major depressive disorder using genome-wide association data.

    Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P et al.

    Molecular psychiatry 2011;16;5;516-32

  • Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells.

    Li Z, Wang L, Zhang W, Fu Y, Zhao H et al.

    Biochemical and biophysical research communications 2007;363;1;165-70

  • Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway.

    Fu Y, Fang Z, Liang Y, Zhu X, Prins P et al.

    Journal of cellular biochemistry 2007;102;3;704-18

Career/Research Highlights

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Bram's Timeline
2015

Statistical Geneticist, Analytical Genomics of Complex Traits group, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

2013

Statistical Geneticist, Cardiogenetics Lab, St George's University of London, London, United Kingdom

2010

Start of PhD, Genetic Epidemiology & Bioinformatics group, University of Groningen, The Netherlands

2008

Reseacher at the Institute Pasteur Korea, Seoul, South Korea

Awarded MSc in Medical Biology, University of Groningen, The Netherlands