Dr Kalliope Panoutsopoulou | Career Development Fellow

This person is a member of Sanger Institute Alumni.

Panoutsopoulou, Kalliope

Kalliope Panoutsopoulou worked in Human Genetics from December 2008 until February 2019 researching the genetic causes of common complex diseases and medically-relevant traits. She became a Career Development Fellow in 2013, leading research on the genetic and environmental determinants of osteoarthritis and related traits.

During her 10 years as a statistical geneticist at the Institute, in collaboration with the arcOGEN and TREAT-OA consortia, Kalliope identified numerous genetic loci associated with osteoarthritis, yielding important insights into the disease’s causes, heritability and comorbidities. She identified the first genetic link of osteoarthritis and obesity demonstrating the causal role of obesity in osteoarthritis, and the first genetic link of osteoarthritis and diabetes that is not mediated via obesity. Kalliope was involved in population genetics studies of isolated populations from the HELIC study and contributed to large-scale meta-analyses from the UK10K, EGG and GIANT consortia that led to the identification of numerous cardio-metabolic and anthropometric loci.


 

Publications

  • A novel variant in GLIS3 is associated with osteoarthritis.

    Casalone E, Tachmazidou I, Zengini E, Hatzikotoulas K, Hackinger S et al.

    Annals of the rheumatic diseases 2018;77;4;620-623

  • Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.

    Panoutsopoulou K, Thiagarajah S, Zengini E, Day-Williams AG, Ramos YF et al.

    Annals of the rheumatic diseases 2017;76;7;1199-1206

  • A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.

    Asimit JL, Panoutsopoulou K, Wheeler E, Berndt SI, GIANT consortium et al.

    Genetic epidemiology 2015;39;8;624-34

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

    Panoutsopoulou K, Hatzikotoulas K, Xifara DK, Colonna V, Farmaki AE et al.

    Nature communications 2014;5;5345

  • Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.

    Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V et al.

    American journal of human genetics 2014;94;2;176-85

  • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

    Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD et al.

    Annals of the rheumatic diseases 2014;73;12;2130-6

  • The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

    Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA et al.

    Annals of the rheumatic diseases 2014;73;12;2082-6

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

    arcOGEN Consortium, arcOGEN Collaborators, Zeggini E, Panoutsopoulou K, Southam L et al.

    Lancet (London, England) 2012;380;9844;815-23

  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.

    Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G et al.

    Annals of the rheumatic diseases 2011;70;5;864-7

  • A novel variant in GLIS3 is associated with osteoarthritis.

    Casalone E, Tachmazidou I, Zengini E, Hatzikotoulas K, Hackinger S et al.

    Annals of the rheumatic diseases 2018;77;4;620-623

  • Maternal and fetal genetic contribution to gestational weight gain.

    Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R et al.

    International journal of obesity (2005) 2018;42;4;775-784

  • Key Concepts in Genetic Epidemiology.

    Panoutsopoulou K and Wheeler E

    Methods in molecular biology (Clifton, N.J.) 2018;1793;7-24

  • Quality Control of Common and Rare Variants.

    Panoutsopoulou K and Walter K

    Methods in molecular biology (Clifton, N.J.) 2018;1793;25-36

  • Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.

    Panoutsopoulou K, Thiagarajah S, Zengini E, Day-Williams AG, Ramos YF et al.

    Annals of the rheumatic diseases 2017;76;7;1199-1206

  • Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

    Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J et al.

    American journal of human genetics 2017;100;6;865-884

  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

    Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C et al.

    Nature genetics 2016;48;11;1303-1312

  • Genome-wide associations for birth weight and correlations with adult disease.

    Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN et al.

    Nature 2016

  • A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.

    Asimit JL, Panoutsopoulou K, Wheeler E, Berndt SI, GIANT consortium et al.

    Genetic epidemiology 2015;39;8;624-34

  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

    Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF et al.

    PLoS genetics 2015;11;10;e1005378

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.

    Huang J, Howie B, McCarthy S, Memari Y, Walter K et al.

    Nature communications 2015;6;8111

  • Investigation of association between hip osteoarthritis susceptibility loci and radiographic proximal femur shape.

    Lindner C, Thiagarajah S, Wilkinson JM, Panoutsopoulou K, Day-Williams AG et al.

    Arthritis & rheumatology (Hoboken, N.J.) 2015;67;8;2076-84

  • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

    Interleukin 1 Genetics Consortium

    The lancet. Diabetes & endocrinology 2015;3;4;243-53

  • A novel common variant in DCST2 is associated with length in early life and height in adulthood.

    van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E et al.

    Human molecular genetics 2015;24;4;1155-68

  • The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

    Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA et al.

    Annals of the rheumatic diseases 2014;73;12;2082-6

  • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

    Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD et al.

    Annals of the rheumatic diseases 2014;73;12;2130-6

  • Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.

    Panoutsopoulou K, Hatzikotoulas K, Xifara DK, Colonna V, Farmaki AE et al.

    Nature communications 2014;5;5345

  • Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.

    Ramos YF, Metrustry S, Arden N, Bay-Jensen AC, Beekman M et al.

    Journal of medical genetics 2014;51;9;596-604

  • Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

    Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM et al.

    Human molecular genetics 2014;23;16;4452-64

  • Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.

    Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, Arden N et al.

    Arthritis & rheumatology (Hoboken, N.J.) 2014;66;4;940-9

  • Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.

    Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V et al.

    American journal of human genetics 2014;94;2;176-85

  • Advances in osteoarthritis genetics.

    Panoutsopoulou K and Zeggini E

    Journal of medical genetics 2013;50;11;715-24

  • In search of low-frequency and rare variants affecting complex traits.

    Panoutsopoulou K, Tachmazidou I and Zeggini E

    Human molecular genetics 2013;22;R1;R16-21

  • The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.

    Evangelou E, Valdes AM, Castano-Betancourt MC, Doherty M, Doherty S et al.

    Annals of the rheumatic diseases 2013;72;7;1264-5

  • Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.

    Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L et al.

    Annals of the rheumatic diseases 2013;72;6;935-41

  • Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.

    Ma RC, Hu C, Tam CH, Zhang R, Kwan P et al.

    Diabetologia 2013;56;6;1291-305

  • Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study.

    Ntalla I, Panoutsopoulou K, Vlachou P, Southam L, William Rayner N et al.

    Annals of human genetics 2013;77;3;268-74

  • A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.

    Tachmazidou I, Dedoussis G, Southam L, Farmaki AE, Ritchie GR et al.

    Nature communications 2013;4;2872

  • No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.

    Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW et al.

    Annals of the rheumatic diseases 2013;72;1;136-9

  • Genome-wide meta-analysis of common variant differences between men and women.

    Boraska V, Jerončić A, Colonna V, Southam L, Nyholt DR et al.

    Human molecular genetics 2012;21;21;4805-15

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

    arcOGEN Consortium, arcOGEN Collaborators, Zeggini E, Panoutsopoulou K, Southam L et al.

    Lancet (London, England) 2012;380;9844;815-23

  • Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

    Boraska V, Day-Williams A, Franklin CS, Elliott KS, Panoutsopoulou K et al.

    PloS one 2012;7;3;e31369

  • Do genome-wide association scans have potential for translation?

    Lopes MC, Zeggini E and Panoutsopoulou K

    Clinical chemistry and laboratory medicine 2011;50;2;255-60

  • A variant in MCF2L is associated with osteoarthritis.

    Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T et al.

    American journal of human genetics 2011;89;3;446-50

  • Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis.

    Eyre S, Ke X, Lawrence R, Bowes J, Panoutsopoulou K et al.

    Arthritis and rheumatism 2011;63;6;1522-6

  • The effect of genome-wide association scan quality control on imputation outcome for common variants.

    Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C et al.

    European journal of human genetics : EJHG 2011;19;5;610-4

  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.

    Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G et al.

    Annals of the rheumatic diseases 2011;70;5;864-7

  • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

    Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y et al.

    Annals of the rheumatic diseases 2011;70;2;349-55

  • Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis.

    Bowes J, Lawrence R, Eyre S, Panoutsopoulou K, Orozco G et al.

    Human genetics 2010;128;6;627-33

  • Finding common susceptibility variants for complex disease: past, present and future.

    Panoutsopoulou K and Zeggini E

    Briefings in functional genomics & proteomics 2009;8;5;345-52

  • Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation.

    Wu J, Zhang N, Hayes A, Panoutsopoulou K and Oliver SG

    Proceedings of the National Academy of Sciences of the United States of America 2004;101;9;3148-53

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Kalliope's Timeline
2013

Started as Arthritis Research UK Career Development Fellow, Wellcome Trust Sanger Institute, Hinxton, UK

2010

Started as Staff Scientist, Wellcome Trust Sanger Institute, Hinxton, UK

2008

Started as Postdoctoral Fellow, Wellcome Trust Centre for Human Genetics, Oxford, UK & Wellcome Trust Sanger Institute, Hinxton, UK

2005

Career Break

2003

Awarded PhD Degree in Genetics, University of Manchester, Manchester, UK

2002

Started as Research Associate, University of Manchester, Manchester, UK

1998

Awarded BSc in Biochemistry & Applied Molecular Biology