Dr Samuel Otieno Oyola | Staff Scientist

This person is a member of Sanger Institute Alumni.

Oyola, Samuel Otieno

I am a Molecular and Cellular Biologist with strong interest in Genomics and Biotechnology. I am currently working on malaria genome variation analysis. My focus is on the development of tools that facilitate high-throughput sequencing of clinical samples and genome analysis. My goal is to translate current high-throughput genomic technologies into basic tools for healthcare applications.

Publications

  • Optimized whole-genome amplification strategy for extremely AT-biased template.

    Oyola SO, Manske M, Campino S, Claessens A, Hamilton WL et al.

    DNA research : an international journal for rapid publication of reports on genes and genomes 2014;21;6;661-71

  • Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

    Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J et al.

    Nature 2012;487;7407;375-9

  • Optimal enzymes for amplifying sequencing libraries.

    Quail MA, Otto TD, Gu Y, Harris SR, Skelly TF et al.

    Nature methods 2011;9;1;10-1

  • Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

    Oyola SO, Otto TD, Gu Y, Maslen G, Manske M et al.

    BMC genomics 2012;13;1

  • Comparative genomic analysis of three Leishmania species that cause diverse human disease.

    Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC et al.

    Nature genetics 2007;39;7;839-47

  • Functional analysis of Leishmania cyclopropane fatty acid synthetase.

    Oyola SO, Evans KJ, Smith TK, Smith BA, Hilley JD et al.

    PloS one 2012;7;12;e51300

  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

    Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S et al.

    Nature genetics 2013;45;6;648-55

  • Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J et al.

    Nature genetics 2015;47;3;226-34

  • A kinetoplastid BRCA2 interacts with DNA replication protein CDC45.

    Oyola SO, Bringaud F and Melville SE

    International journal for parasitology 2009;39;1;59-69

  • Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J et al.

    Nature genetics 2015;47;3;226-34

  • Optimized whole-genome amplification strategy for extremely AT-biased template.

    Oyola SO, Manske M, Campino S, Claessens A, Hamilton WL et al.

    DNA research : an international journal for rapid publication of reports on genes and genomes 2014;21;6;661-71

  • A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

    Wendler JP, Okombo J, Amato R, Miotto O, Kiara SM et al.

    PloS one 2014;9;5;e96486

  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

    Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S et al.

    Nature genetics 2013;45;6;648-55

  • Efficient depletion of host DNA contamination in malaria clinical sequencing.

    Oyola SO, Gu Y, Manske M, Otto TD, O'Brien J et al.

    Journal of clinical microbiology 2013;51;3;745-51

  • Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

    Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J et al.

    Nature 2012;487;7407;375-9

  • Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

    Oyola SO, Otto TD, Gu Y, Maslen G, Manske M et al.

    BMC genomics 2012;13;1

  • Functional analysis of Leishmania cyclopropane fatty acid synthetase.

    Oyola SO, Evans KJ, Smith TK, Smith BA, Hilley JD et al.

    PloS one 2012;7;12;e51300

  • Optimal enzymes for amplifying sequencing libraries.

    Quail MA, Otto TD, Gu Y, Harris SR, Skelly TF et al.

    Nature methods 2011;9;1;10-1

  • A kinetoplastid BRCA2 interacts with DNA replication protein CDC45.

    Oyola SO, Bringaud F and Melville SE

    International journal for parasitology 2009;39;1;59-69

  • Mucosal prime-boost vaccination for tuberculosis based on TLR triggering OprI lipoprotein from Pseudomonas aeruginosa fused to mycolyl-transferase Ag85A.

    Gartner T, Baeten M, Otieno S, Revets H, De Baetselier P and Huygen K

    Immunology letters 2007;111;1;26-35

  • Comparative genomic analysis of three Leishmania species that cause diverse human disease.

    Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC et al.

    Nature genetics 2007;39;7;839-47

Oyola, Samuel Otieno
Samuel's Timeline
2010

Joined Wellcome Trust Sanger Institute to work on Malaria Genetics using NGS technologies

2007

Joined Prof Debbie Smith's lab at the University of York as Postdoctoral Fellow to study Leishmania functional genomics

2006

PhD University of Cambridge ("Identification and functional characterization of a BRCA2 orthologue in Trypanosoma brucei")

2002

MSc awarded in Molecular Biology (Vrije Universiteit Brussel (VUB), Belgium)

2000

International Livestock Research Institute (Nairobi, Kenya)

1998

Bsc awarded (Egerton University, Kenya)