Dr Sarah Moody | Postdoctoral Fellow

Moody, Sarah

I am currently working on one of the CRUK Grand Challenge projects, a series of £20m grants awarded to tackle the toughest questions in cancer. As part of the Grand Challenge: Mutographs team I am involved in performing mutation signature analysis on whole genome sequencing data from 5000 patients with 5 different cancer types (Pancreas, Colorectal, Kidney, Esophagael Squamous Cell Carcinoma (ESCC) and Esophageal Adenocarcinoma (EAC)). All 5 of these cancer types display a remarkable difference in incidence rates across different regions of the world but the factors driving this are poorly understood. The aim of the Mutographs project is to identify novel preventable causes of cancer by comparing the mutational signatures present in cancers from areas of high and low incidence, and combining this with extensive epidemiology data collected from each patient to identify the factors driving the increased risk. 

Publications

  • Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites.

    Moody S, Thompson JS, Chuang SS, Liu H, Raderer M et al.

    Haematologica 2018;103;8;1329-1336

  • Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.

    Moody S, Escudero-Ibarz L, Wang M, Clipson A, Ochoa Ruiz E et al.

    The Journal of pathology 2017;243;1;3-8

  • Somatic Mutation Screening Using Archival Formalin-Fixed, Paraffin-Embedded Tissues by Fluidigm Multiplex PCR and Illumina Sequencing.

    Wang M, Escudero-Ibarz L, Moody S, Zeng N, Clipson A et al.

    The Journal of molecular diagnostics : JMD 2015;17;5;521-32

  • Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites.

    Moody S, Thompson JS, Chuang SS, Liu H, Raderer M et al.

    Haematologica 2018;103;8;1329-1336

  • Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.

    Moody S, Escudero-Ibarz L, Wang M, Clipson A, Ochoa Ruiz E et al.

    The Journal of pathology 2017;243;1;3-8

  • Somatic Mutation Screening Using Archival Formalin-Fixed, Paraffin-Embedded Tissues by Fluidigm Multiplex PCR and Illumina Sequencing.

    Wang M, Escudero-Ibarz L, Moody S, Zeng N, Clipson A et al.

    The Journal of molecular diagnostics : JMD 2015;17;5;521-32

Moody, Sarah
Sarah's Timeline
2018

Postdoctoral Research Fellow - Wellcome Sanger Institute

2016

Research Associate - Department of Pathology, University of Cambridge

2015

PhD Pathology - University of Cambridge

2010

BSc Genetics - University of York