Jeremy McRae | Statistical Geneticist

This person is a member of Sanger Institute Alumni.

McRae, Jeremy

Jeremy is a geneticist focusing on analysis of large-scale genomic data in rare disease.

Currently my main focus is developing computational and statistical methods to tease apart the genetics of developmental disorders. This is part of the Deciphering Developmental Disorders study, which is sequencing 12000 children with undiagnosed developmental disorders. I'm screening the hundreds of thousands of genetic variants in each child for the few genetic variants that could cause the child's disorder. Additionally, I'm trying to discover previously unknown genes where genetic defects cause dominant or recessive diseases.

Previously I studied the genetics of smell. I successfully found genetic variants that strongly determine how well people can smell several food odors.

Publications

  • Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.

    Akawi N, McRae J, Ansari M, Balasubramanian M, Blyth M et al.

    Nature genetics 2015;47;11;1363-9

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • Identification of regions associated with variation in sensitivity to food-related odors in the human genome.

    McRae JF, Jaeger SR, Bava CM, Beresford MK, Hunter D et al.

    Current biology : CB 2013;23;16;1596-600

  • A Mendelian trait for olfactory sensitivity affects odor experience and food selection.

    Jaeger SR, McRae JF, Bava CM, Beresford MK, Hunter D et al.

    Current biology : CB 2013;23;16;1601-5

  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.

    McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H and Newcomb RD

    Chemical senses 2012;37;7;585-93

  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • A Mendelian trait for olfactory sensitivity affects odor experience and food selection.

    Jaeger SR, McRae JF, Bava CM, Beresford MK, Hunter D et al.

    Current biology : CB 2013;23;16;1601-5

  • Identification of regions associated with variation in sensitivity to food-related odors in the human genome.

    McRae JF, Jaeger SR, Bava CM, Beresford MK, Hunter D et al.

    Current biology : CB 2013;23;16;1596-600

  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.

    McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H and Newcomb RD

    Chemical senses 2012;37;7;585-93

McRae, Jeremy
Jeremy's Timeline
2013

Joined Wellcome Trust Sanger Institute as postdoctoral researcher. Genetics of rare developmental disorders.

2008

Joined Plant & Food Research, New Zealand as postdoctoral researcher. Genetics of sensitivity to food-odors and food preference.

2003

Started PhD in Genetics, University of Otago, Christchurch, New Zealand