Dr Andrea Manrique-Rincón | Postdoctoral Fellow

Manrique-Rincon, Andrea

I am deeply interested in T cells and the immune response againts cancer. The tumour microenvironment can be challenging to target for the immune system, as it can develop several immunosuppresive mechanisms that inhibt the correct function of the T cells. However, the T cells can be modified to enhance this response and eliminate the tumour cells. I found this fascinating, and I am working to identify new targets to enhance T cell survival and/or function within the tumour microenvironment.

During my doctoral studies I worked on new strategies for cancer immunotherapy. I worked on inhibition of regulatory T cells using viral vector and aptamers to carrying different siRNA and gRNAs. I used also combinations of antitumoral vaccines that expressed immunomodulators like 4-1BBL, OX40L, and GM-CSF to enhance the immune response against cancer.

Publications

  • Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.

    Manrique-Rincón AJ, Beraldo CM, Toscaro JM and Bajgelman MC

    Frontiers in immunology 2017;8;1150

  • Development of a flow cytometry assay which allows to evaluate the efficiency of immunomodulatory vaccines to enhance T cell-mediated antitumor response.

    Manrique-Rincón AJ, de Carvalho AC, Ribeiro de Camargo ME, Franchini KG and Bajgelman MC

    Journal of biotechnology 2018;284;11-16

  • Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.

    Manrique-Rincón AJ, Beraldo CM, Toscaro JM and Bajgelman MC

    Frontiers in immunology 2017;8;1150

Manrique-Rincon, Andrea
Andrea's Timeline
2018

Postdoctoral Fellow, Wellcome Trust Sanger Institute

2017

Ph.D. Medical School, University of Campinas (UNICAMP)

2013

Biology B.Sc., Universidad de Antioquia