Elizabeth Klemm, PhD | Postdoctoral Fellow

This person is a member of Sanger Institute Alumni.

Klemm, Elizabeth

Elizabeth Klemm is a postdoctoral fellow at the Wellcome Sanger Institute. Her research interests centre around host-pathogen interactions as they relate to global health and infectious disease. Integrating genomics tools and laboratory-based techniques, she has led studies on antimicrobial resistance, within-host evolution, and pathogen immune evasion. Her work has enabled a better undertanding of host adaptation in emerging infectious diseases. She obtained her PhD at MIT.


  • Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

    Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR et al.

    Nature microbiology 2016;1;15023

  • Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

    Klemm EJ, Spooner E and Ploegh HL

    The Journal of biological chemistry 2011;286;43;37602-14

  • SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

    Mueller B, Klemm EJ, Spooner E, Claessen JH and Ploegh HL

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;34;12325-30

  • Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium.

    Ondari EM, Heath JN, Klemm EJ, Langridge G, Barquist L et al.

    Infection and immunity 2017;85;9

  • The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

    Johnson R, Byrne A, Berger CN, Klemm E, Crepin VF et al.

    Journal of bacteriology 2017;199;4

  • An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.

    Tran Vu Thieu N, Trinh Van T, Tran Tuan A, Klemm EJ, Nguyen Ngoc Minh C et al.

    The Journal of infection 2017;75;2;104-114

  • A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.

    Makendi C, Page AJ, Wren BW, Le Thi Phuong T, Clare S et al.

    PLoS neglected tropical diseases 2016;10;2;e0004446

  • Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.

    Wong VK, Baker S, Pickard DJ, Parkhill J, Page AJ et al.

    Nature genetics 2015;47;6;632-9

  • ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization.

    Perkins TT, Davies MR, Klemm EJ, Rowley G, Wileman T et al.

    Molecular microbiology 2013;87;3;526-38

  • XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.

    McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B et al.

    Journal of immunology (Baltimore, Md. : 1950) 2009;183;6;3690-9

  • Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.

    Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD et al.

    Journal of immunology (Baltimore, Md. : 1950) 2006;177;12;8422-31

  • Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.

    Klemm E and Dougan G

    Cell host & microbe 2016;19;5;599-610

Klemm, Elizabeth