Elizabeth Klemm is a postdoctoral fellow at the Wellcome Sanger Institute. Her research interests centre around host-pathogen interactions as they relate to global health and infectious disease. Integrating genomics tools and laboratory-based techniques, she has led studies on antimicrobial resistance, within-host evolution, and pathogen immune evasion. Her work has enabled a better undertanding of host adaptation in emerging infectious diseases. She obtained her PhD at MIT.
Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.
Nature microbiology 2016;1;15023
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
The Journal of biological chemistry 2011;286;43;37602-14
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105;34;12325-30
Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium.
Infection and immunity 2017;85;9
The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.
Journal of bacteriology 2017;199;4
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.
The Journal of infection 2017;75;2;104-114
A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.
PLoS neglected tropical diseases 2016;10;2;e0004446
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.
Nature genetics 2015;47;6;632-9
ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization.
Molecular microbiology 2013;87;3;526-38
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183;6;3690-9
Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177;12;8422-31
Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.
Cell host & microbe 2016;19;5;599-610