Dr James Hewinson | Laboratory Manager

Hewinson, James

The laboratory manager for the Experimental Cancer Genetics group.

My day to day responsibility is to run of the labs of the Experimental cancer genetics group. However I have always been keen to apply myself further. Consequently I have taken on board further roles within the Morgan Building, including working as a Local Coordinator, Fire Marshal, and Cell Culture manager. I am also keen to contribute to the campus as a whole, therefore I have taken the position of GRL Pension Scheme Trustee and Employee Partner, and work with other departments on site to improve processes.

My background and training have been within biological research. Fortunately I still have the opportunity to apply myself to research, working on various research projects within the group.


  • ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

    Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I et al.

    Nature communications 2019;10;1;2213

  • Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.

    McCreery MQ, Halliwill KD, Chin D, Delrosario R, Hirst G et al.

    Nature medicine 2015;21;12;1514-20

  • Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats.

    Hickey L, Li Y, Fyson SJ, Watson TC, Perrins R et al.

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2014;34;12;4148-60

  • Viral gene delivery: optimized protocol for production of high titer lentiviral vectors.

    Hewinson J, Paton JF and Kasparov S

    Methods in molecular biology (Clifton, N.J.) 2013;998;65-75

  • Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.

    Xu H, Oliveira-Sales EB, McBride F, Liu B, Hewinson J et al.

    Cardiovascular research 2012;96;3;552-60

  • A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.

    Thompson BA, Storm MP, Hewinson J, Hogg S, Welham MJ and MacKenzie AB

    Cellular signalling 2012;24;3;770-8

  • NOS antagonism using viral vectors as an experimental strategy: implications for in vivo studies of cardiovascular control and peripheral neuropathies.

    Liu B, Hewinson J, Xu H, Montero F, Sunico CR et al.

    Methods in molecular biology (Clifton, N.J.) 2011;704;197-223

  • Optogenetic experimentation on astrocytes.

    Figueiredo M, Lane S, Tang F, Liu BH, Hewinson J et al.

    Experimental physiology 2011;96;1;40-50

  • Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration.

    Marina N, Abdala AP, Trapp S, Li A, Nattie EE et al.

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30;37;12466-73

  • A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes.

    Hewinson J, Moore SF, Glover C, Watts AG and MacKenzie AB

    Journal of immunology (Baltimore, Md. : 1950) 2008;180;12;8410-20

  • P2X(7) receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators.

    Hewinson J and Mackenzie AB

    Biochemical Society transactions 2007;35;Pt 5;1168-70

  • Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme.

    Hewinson J, Stevens CR and Millar TM

    Redox report : communications in free radical research 2004;9;2;71-9

Hewinson, James
James's Timeline

Laboratory Manager. Department of Experimental Cancer Genetics. WTSI.


Laboratory Manager. School of Physiology and Pharmacology. Bristol University.


Post Doctorial Research. Department of Pharmacy and Pharmacology. University of Bath.

Graduation - PhD. Department of Medical Sciences. University of Bath.


Graduation - BSc First Class (Hons). Applied Biological Sciences. University of the West of England.