Bob Hancock's research interests include small cationic peptides as novel antimicrobials and modulators of innate immunity, the development of novel treatments for antibiotic resistant infections, the systems biology of innate immunity, inflammatory diseases and Pseudomonas aeruginosa, and antibiotic uptake and resistance. At the Sanger Institute he is involved in the cellular phenotyping programme, converting mutated mouse embryonic stem cells and human induced pluripotent stem cells into macrophages with the aim of understanding functional networks of genes involved in infections and inflammation.
Bob Hancock is a Professor of Microbiology & Immunology, UBC, and a Canada Research Chair in Health and Genomics. Bob has published more than 660 papers and reviews, has 50 patents awarded, and is an ISI highly cited author in Microbiology with more than 63,000 citations and an h-index of 130. He has won several awards including the Aventis Pharmaceuticals Award, the leading award for research on antimicrobials, and Canada’s three top prizes for Health Research, and is an Officer of the Order of Canada. He was a co-founder of Migenix, Inimex Pharmaceuticals, ABT Innovations, Sepset, and the Centre for Drug Research and Development.
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
An anti-infective peptide that selectively modulates the innate immune response.
Nature biotechnology 2007;25;4;465-72
InnateDB: facilitating systems-level analyses of the mammalian innate immune response.
Molecular systems biology 2008;4;218
Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria.
Science translational medicine 2012;4;135;135ra64
The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.
Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190;3;1227-38
Broad-spectrum anti-biofilm peptide that targets a cellular stress response.
PLoS pathogens 2014;10;5;e1004152
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.
Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.
Scientific reports 2015;5;8908
NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data.
Nature protocols 2015;10;6;823-44