David's role is to provide imaging support for team 15 and Pathogen Variation using electron and advanced light microscopy. His expertise lies in ultrastructure techniques, including fine structure immunocytochemistry, to study interactions between host cells and microorganisms. The microscope suite in Gordon Dougan's lab houses TEM, SEM, confocal and microinjection microscopes with a variety of analysis software platforms.
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.
Infection and immunity 2015;83;7;2926-34
An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei.
PLoS pathogens 2015;11;3;e1004749
The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.
Scientific reports 2015;5;7947
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss.
PLoS genetics 2014;10;10;e1004688
Juno is the egg Izumo receptor and is essential for mammalian fertilization.
Molecular characterization of the viaB locus encoding the biosynthetic machinery for Vi capsule formation in Salmonella Typhi.
PloS one 2012;7;9;e45609
IFITM3 restricts the morbidity and mortality associated with influenza.
A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo.
PLoS pathogens 2011;7;7;e1002131
Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.
Journal of cell science 2011;124;Pt 4;565-77
Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.
Infection and immunity 2009;77;12;5478-85