Katharina is a postdoctoral fellow in the group of Eric Miska, interested in environmentally triggered psychopathology and the role of epigenetics as a mean of storage of experiences. Her research focuses on epigenetic mechanisms underlying the transmission of acquired traits.
My research explores mechanisms underlying the epigenetic transmission of acquired traits, with a particular focus on inherited disease risk. During my phd studies in Isabelle Mansuy´s lab of neuroepigenetics at ETH Zürich I demonstrated the involvement of sperm RNAs in the transgenerational effects of early life stress. I am now interested in extrapolating these findings to other models.
Early life stress in fathers improves behavioural flexibility in their offspring.
Nature communications 2014;5;5466
Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress.
Molecular psychiatry 2015;20;5;621-31
Mitochondrial dysfunction and decrease in body weight of transgenic knock-in mouse model for TDP-43: the question of glucose?
The Journal of biological chemistry 2014;289;26;18593
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
Nature neuroscience 2014;17;5;667-9
Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance?
BioEssays : news and reviews in molecular, cellular and developmental biology 2014;36;5;491-502
Epigenetics of memory and plasticity.
Progress in molecular biology and translational science 2014;122;305-40
Epigenetic regulation in neurodevelopment and neurodegenerative diseases.
Transgenerational epigenetic effects on brain functions.
Biological psychiatry 2013;73;4;313-20