Professor Gordon Dougan | Former Senior Group Leader

This person is a member of Sanger Institute Alumni.

Dougan, Gordon

Professor Gordon Dougan is now based at the University of Cambridge, and can be contacted at:

Professor Gordon Dougan's research focuses on the genetic analysis of host/pathogen interactions during infection, particularly those involving enteric bacteria. He has worked extensively in both academia and industry, making important contributions in the field of vaccinology where he has worked to improve vaccine delivery to poorly resourced regions.

Gordon has extensive teaching experience at both the undergraduate and postgraduate level. He has served on several editorial boards and regularly reviews manuscripts for high-impact journals. He is a consultant for industry and has founded biotechnology companies, including the single-chain antibody company VHSquared.

Gordon is a Fellow of the Royal Society, the Biology Society, the Academy of Medical Sciences and is an EMBO (European Molecular Biology Organization) member. He established the Centre for Molecular Microbiology and Infection (including a raising funding for a building) at Imperial College London and was the Board of Management representative for Pathogen Research for ten years (2004-2014) at the Sanger Institute where he is currently a Senior Group Leader.

Research at the Sanger Institute

Gordon was a Senior Group Leader at the Sanger Institute. His research at the Institute focused on the use of genomics to study host/pathogen interactions during infection. The team consisted of 10-15 individuals including core scientists (in vivo, FACS (Fluorescence-activated cell sorting) and microscopy), Postdoctoral Fellows and PhD students.

On joining the Sanger Institute in 2004, Gordon reshaped the science, building new facilities and recruiting new Faculty. He nurtured links with the internal Mouse and Human Genetics programmes and established a global network of collaborators built around open-access policies. Gordon's Faculty research investigated host/pathogen interactions associated with enteric bacterial pathogens, principally S. enterica serovar Typhi. He also directed other projects investigating the genetics of host susceptibility to infection through mouse and zebrafish infection screens.


Gordon has been a university lecturer both in the UK and abroad (The Republic of Ireland) and has run or participated in many teaching courses for undergraduates, MSc or PhD students (both lecture courses and practical). He has lectured to science, dental, medical and pharmacy students and coordinated courses and assessments for these groups. Gordon has supervised over 60 successful PhD students, many of whom are now independent scientific leaders or occupy important positions in industry or government organisations. These include more than ten full Professors in the UK and abroad. Gordon also regularly participates in or organises scientific courses targeting young scientists and clinicians.

Industry and International work

Gordon worked for more than ten years for the multi-national pharmaceutical company, The Wellcome Foundation, which is now part of GSK. During this period he became Head of Molecular Biology, managing teams working on vaccines, humanised antibodies and scale-up systems. He contributed to the discovery of pertactin as a key protective antigen for acellular whooping cough vaccines and is now an advisor for many companies, serving as an Scientific Advisory Board (SAB) or Board member. Gordon was Chair of the SAB for Novartis Vaccines & Diagnostics for more than ten years and helped found the Novartis Vaccine Global Health Institute (NVGH).

He is on the board of The Hilleman Laboratories, a joint enterprise between Merck and The Wellcome Trust and has founded spin-out companies and served as a Trustee at the International Vaccine Institute in Korea. Gordon is also currently an SAB member for ICDDR-B (International Centre for Diarrhoeal Disease Research, Bangladesh) and has served as a member of several WHO (World Health Organization) Committees.


  • Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa.

    Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM et al.

    Nature genetics 2012;44;11;1215-21

  • IFITM3 restricts the morbidity and mortality associated with influenza.

    Everitt AR, Clare S, Pertel T, John SP, Wash RS et al.

    Nature 2012;484;7395;519-23

  • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.

    Lawley TD, Clare S, Walker AW, Stares MD, Connor TR et al.

    PLoS pathogens 2012;8;10;e1002995

  • Evidence for several waves of global transmission in the seventh cholera pandemic.

    Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH et al.

    Nature 2011;477;7365;462-5

  • The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children.

    MacLennan CA, Gondwe EN, Msefula CL, Kingsley RA, Thomson NR et al.

    The Journal of clinical investigation 2008;118;4;1553-62

  • A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi.

    Baker S, Holt K, Whitehead S, Goodhead I, Perkins T et al.

    Molecular microbiology 2007;66;5;1207-18

  • Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.

    Stecher B, Robbiani R, Walker AW, Westendorf AM, Barthel M et al.

    PLoS biology 2007;5;10;2177-89

  • Requirement of bic/microRNA-155 for normal immune function.

    Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P et al.

    Science (New York, N.Y.) 2007;316;5824;608-11

  • Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2.

    Mukhopadhyay S, Heinz E, Porreca I, Alasoo K, Yeung A et al.

    The Journal of experimental medicine 2020;217;2

  • SLAMF9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.

    Wilson TJ, Clare S, Mikulin J, Johnson CM, Harcourt K et al.

    Immunology 2019

  • High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.

    Abeler-Dörner L, Laing AG, Lorenc A, Ushakov DS, Clare S et al.

    Nature immunology 2019

  • The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.

    Dunstan RA, Pickard D, Dougan S, Goulding D, Cormie C et al.

    Molecular microbiology 2019;112;6;1831-1846

  • Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.

    Britto CD, Dyson ZA, Mathias S, Bosco A, Dougan G et al.

    The Journal of antimicrobial chemotherapy 2019

  • A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

    Yeung ATY, Choi YH, Lee AHY, Hale C, Ponstingl H et al.

    mBio 2019;10;5

  • An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.

    Van Puyvelde S, Pickard D, Vandelannoote K, Heinz E, Barbé B et al.

    Nature communications 2019;10;1;4280

  • Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS.

    Pérez-Vázquez M, Sola Campoy PJ, Ortega A, Bautista V, Monzón S et al.

    The Journal of antimicrobial chemotherapy 2019

  • Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center.

    Ellington MJ, Heinz E, Wailan AM, Dorman MJ, de Goffau M et al.

    Genome biology 2019;20;1;184

  • Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases.

    Blohmke CJ, Muller J, Gibani MM, Dobinson H, Shrestha S et al.

    EMBO molecular medicine 2019;e10431

  • Molecular epidemiology and intercontinental spread of cholera.

    Mutreja A and Dougan G

    Vaccine 2019

  • Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.

    Gibani MM, Jones E, Barton A, Jin C, Meek J et al.

    Nature medicine 2019

  • Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

    Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA et al.

    Nature genetics 2019;51;6;1035-1043

  • Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens.

    Lees EA, Forbester JL, Forrest S, Kane L, Goulding D and Dougan G

    Journal of visualized experiments : JoVE 2019;147

  • Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.

    Ashton PM, Thanh LT, Trieu PH, Van Anh D, Trinh NM et al.

    Nature communications 2019;10;1;2035

  • Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.

    Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY et al.

    The Journal of experimental medicine 2019;216;4;757-771

  • Antibiotic Resistance and Typhoid.

    Dyson ZA, Klemm EJ, Palmer S and Dougan G

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019;68;Supplement_2;S165-S170

  • Wave 2 strains of atypical Vibrio cholerae El Tor caused the 2009-2011 cholera outbreak in Papua New Guinea.

    Greenhill AR, Mutreja A, Bulach D, Belousoff MJ, Jonduo MH et al.

    Microbial genomics 2019;5;3

  • Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1.

    Heinz E, Ejaz H, Bartholdson Scott J, Wang N, Gujaran S et al.

    Scientific reports 2019;9;1;2392

  • Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

    Dougan G, Dowson C, Overington J and Next Generation Antibiotic Discovery Symposium Participants

    Drug discovery today 2019;24;2;452-461

  • An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation.

    Poole E, Huang CJZ, Forbester J, Shnayder M, Nachshon A et al.

    Frontiers in microbiology 2019;10;2233

  • Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

    Forbester JL, Hannan N, Vallier L and Dougan G

    Methods in molecular biology (Clifton, N.J.) 2019;1576;157-169

  • DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.

    Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J et al.

    Gut 2019;68;1;49-61

  • FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

    Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A et al.

    PloS one 2019;14;3;e0212481

  • Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

    Kraiczy J, Ross ADB, Forbester JL, Dougan G, Vallier L and Zilbauer M

    Cellular and molecular gastroenterology and hepatology 2019;7;2;285-288

  • GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.

    Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S et al.

    Science signaling 2019;12;562

  • Rapid transcriptional responses to serum exposure are associated with sensitivity and resistance to antibody-mediated complement killing in invasive Salmonella Typhimurium ST313.

    Ondari EM, Klemm EJ, Msefula CL, El Ghany MA, Heath JN et al.

    Wellcome open research 2019;4;74

  • Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.

    Klemm EJ, Wong VK and Dougan G

    Proceedings of the National Academy of Sciences of the United States of America 2018;115;51;12872-12877

  • Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.

    Bohlmann L, De Oliveira DMP, El-Deeb IM, Brazel EB, Harbison-Price N et al.

    mBio 2018;9;6

  • A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.

    Britto CD, Wong VK, Dougan G and Pollard AJ

    PLoS neglected tropical diseases 2018;12;10;e0006779

  • Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.

    Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A et al.

    Proceedings of the National Academy of Sciences of the United States of America 2018;115;40;10118-10123

  • Identification of novel adenovirus genotype 90 in children from Bangladesh.

    Houldcroft CJ, Beale MA, Sayeed MA, Qadri F, Dougan G and Mutreja A

    Microbial genomics 2018

  • New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.

    Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S et al.

    mBio 2018;9;5

  • An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis.

    Torres VVL, Heinz E, Stubenrauch CJ, Wilksch JJ, Cao H et al.

    Molecular microbiology 2018;109;5;584-599

  • Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.

    Wilson HJ, Khokhar F, Enoch DA, Brown NM, Ahluwalia J et al.

    The Journal of hospital infection 2018;100;1;35-39

  • FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.

    Grinter R, Hay ID, Song J, Wang J, Teng D et al.

    PLoS biology 2018;16;8;e2006026

  • Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

    Napolitani G, Kurupati P, Teng KWW, Gibani MM, Rei M et al.

    Nature immunology 2018;19;7;742-754

  • Farewell Stan Stanley Falkow: 1934-2018.

    Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J et al.

    Environmental microbiology 2018;20;7;2322-2333

  • Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.

    Britto CD, Dyson ZA, Duchene S, Carter MJ, Gurung M et al.

    PLoS neglected tropical diseases 2018;12;4;e0006408

  • Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.

    Deo P, Chow SH, Hay ID, Kleifeld O, Costin A et al.

    PLoS pathogens 2018;14;3;e1006945

  • PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data.

    Page AJ, Wailan A, Shao Y, Judge K, Dougan G et al.

    Microbial genomics 2018;4;3

  • Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.

    Alasoo K, Rodrigues J, Mukhopadhyay S, Knights AJ, Mann AL et al.

    Nature genetics 2018;50;3;424-431

  • Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins.

    Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K et al.

    mBio 2018;9;1

  • Comparison of Salmonella enterica serovars Typhi and Typhimurium reveals typhoidal-specific responses to bile.

    Johnson R, Ravenhall M, Pickard D, Dougan G, Byrne A and Frankel G

    Infection and immunity 2017

  • Genomic history of the seventh pandemic of cholera in Africa.

    Weill FX, Domman D, Njamkepo E, Tarr C, Rauzier J et al.

    Science (New York, N.Y.) 2017;358;6364;785-789

  • Integrated view of Vibrio cholerae in the Americas.

    Domman D, Quilici ML, Dorman MJ, Njamkepo E, Mutreja A et al.

    Science (New York, N.Y.) 2017;358;6364;789-793

  • Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.

    Stubenrauch CJ, Dougan G, Lithgow T and Heinz E

    Open biology 2017;7;11

  • Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.

    Ejaz H, Wang N, Wilksch JJ, Page AJ, Cao H et al.

    Emerging infectious diseases 2017;23;11;1872-1875

  • Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391.

    Sullivan MJ, Forde BM, Prince DW, Ipe DS, Ben Zakour NL et al.

    Genome announcements 2017;5;42

  • Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.

    Berger CN, Crepin VF, Roumeliotis TI, Wright JC, Carson D et al.

    Cell metabolism 2017

  • Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).

    Mentzer AV, Tobias J, Wiklund G, Nordqvist S, Aslett M et al.

    Scientific reports 2017;7;1;12514

  • Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

    Kiu R, Caim S, Alcon-Giner C, Belteki G, Clarke P et al.

    Genome biology and evolution 2017;9;10;2707-2714

  • Salmonella enterica serovar Typhi Producing CTX-M-15 Extended Spectrum β-Lactamase in the Democratic Republic of the Congo.

    Phoba MF, Barbé B, Lunguya O, Masendu L, Lulengwa D et al.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017;65;7;1229-1231

  • NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

    Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA et al.

    The Journal of clinical investigation 2017;127;9;3521-3526

  • Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium.

    Ondari EM, Heath JN, Klemm EJ, Langridge G, Barquist L et al.

    Infection and immunity 2017;85;9

  • The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK.

    Meiring JE, Gibani M and TyVAC Consortium Meeting Group

    Vaccine 2017

  • Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.

    Kuijpers TW, Tool ATJ, van der Bijl I, de Boer M, van Houdt M et al.

    The Journal of allergy and clinical immunology 2017;140;1;273-277.e10

  • Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

    Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G et al.

    Nature genetics 2017

  • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

    Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W et al.

    Nature communications 2017;8;15013

  • Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

    Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK et al.

    The Journal of experimental medicine 2017;214;4;1111-1128

  • Typhoid in Africa and vaccine deployment.

    Dougan G

    The Lancet. Global health 2017;5;3;e236-e237

  • The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

    Johnson R, Byrne A, Berger CN, Klemm E, Crepin VF et al.

    Journal of bacteriology 2017;199;4

  • Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

    Blohmke CJ, Hill J, Darton TC, Carvalho-Burger M, Eustace A et al.

    Frontiers in immunology 2017;8;1276

  • Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

    Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT et al.

    Cell metabolism 2016;24;5;740-752

  • New Approaches for Needed Vaccines: Bacteria

    MacLennan,C.A., Mutreja,A. and Dougan,G.

    The Vaccine Book: Second Edition 2016;311-29

  • Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway.

    Yu Y, Tsang JC, Wang C, Clare S, Wang J et al.

    Nature 2016;539;7627;102-106

  • ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

    Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G and Lehner PJ

    Cell reports 2016;17;3;653-659

  • An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.

    Wong VK, Baker S, Connor TR, Pickard D, Page AJ et al.

    Nature communications 2016;7;12827

  • Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

    Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J et al.

    Nature genetics 2016;48;10;1211-1217

  • Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

    Karlsson SL, Thomson N, Mutreja A, Connor T, Sur D et al.

    PLoS neglected tropical diseases 2016;10;10;e0005044

  • C13orf31 (FAMIN) is a central regulator of immunometabolic function.

    Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL et al.

    Nature immunology 2016;17;9;1046-56

  • Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.

    International Typhoid Consortium, Wong VK, Holt KE, Okoro C, Baker S et al.

    PLoS neglected tropical diseases 2016;10;9;e0004781

  • Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

    Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L et al.

    PLoS neglected tropical diseases 2016;10;8;e0004926

  • Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

    Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ et al.

    The Journal of biological chemistry 2016;291;27;14285-99

  • Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.

    Mottram L, Speak AO, Selek RM, Cambridge EL, McIntyre Z et al.

    mBio 2016;7;3

  • Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

    Heinz E, Stubenrauch CJ, Grinter R, Croft NP, Purcell AW et al.

    Genome biology and evolution 2016;8;6;1690-705

  • Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

    Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC et al.

    Nature communications 2016;7;11786

  • The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.

    Pham Thanh D, Thompson CN, Rabaa MA, Sona S, Sopheary S et al.

    PLoS neglected tropical diseases 2016;10;6;e0004785

  • Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

    Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS et al.

    The Journal of experimental medicine 2016;213;6;1061-77

  • Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.

    Klemm E and Dougan G

    Cell host & microbe 2016;19;5;599-610

  • Microevolution of Monophasic Salmonella Typhimurium during Epidemic, United Kingdom, 2005-2010.

    Petrovska L, Mather AE, AbuOun M, Branchu P, Harris SR et al.

    Emerging infectious diseases 2016;22;4;617-24

  • T cell fate and clonality inference from single-cell transcriptomes.

    Stubbington MJT, Lönnberg T, Proserpio V, Clare S, Speak AO et al.

    Nature methods 2016;13;4;329-332

  • Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain.

    Pérez-Vázquez M, Oteo J, García-Cobos S, Aracil B, Harris SR et al.

    The Journal of antimicrobial chemotherapy 2016;71;4;887-96

  • A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.

    Makendi C, Page AJ, Wren BW, Le Thi Phuong T, Clare S et al.

    PLoS neglected tropical diseases 2016;10;2;e0004446

  • Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.

    Holt K, Kenyon JJ, Hamidian M, Schultz MB, Pickard DJ et al.

    Microbial genomics 2016;2;2;e000052

  • Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations.

    Maggiore L, Yu L, Omasits U, Rossi O, Dougan G et al.

    International journal of medical microbiology : IJMM 2016;306;2;99-108

  • Invasive Group A Streptococcus Infection among Children, Rural Kenya.

    Seale AC, Davies MR, Anampiu K, Morpeth SC, Nyongesa S et al.

    Emerging infectious diseases 2016;22;2;224-32

  • Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

    Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR et al.

    Nature microbiology 2016;1;15023

  • Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.

    Ingle DJ, Tauschek M, Edwards DJ, Hocking DM, Pickard DJ et al.

    Nature microbiology 2016;1;15010

  • A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.

    Pham Thanh D, Karkey A, Dongol S, Ho Thi N, Thompson CN et al.

    eLife 2016;5

  • Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen.

    Hart PJ, O'Shaughnessy CM, Siggins MK, Bobat S, Kingsley RA et al.

    PloS one 2016;11;1;e0145945

  • Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.

    Ipe DS, Ben Zakour NL, Sullivan MJ, Beatson SA, Ulett KB et al.

    Infection and immunity 2015;84;1;307-19

  • Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

    Alasoo K, Martinez FO, Hale C, Gordon S, Powrie F et al.

    Scientific reports 2015;5;12524

  • Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.

    Forbester JL, Goulding D, Vallier L, Hannan N, Hale C et al.

    Infection and immunity 2015;83;7;2926-34

  • GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

    Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R et al.

    Science (New York, N.Y.) 2015;348;6242;1481-5

  • Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

    Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F et al.

    mBio 2015;6;3;e00551

  • The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

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Dougan, Gordon