Sophia David is a Postdoctoral Scientist in the Centre for Genomic Pathogen Surveillance (CGPS). Her work involves analysis of whole genome sequencing (WGS) data to study bacterial pathogens.
Using bioinformatic analysis of large WGS data sets, my current work aims to understand the emergence and spread of carbapenemase-producing Enterobacteriaceae (CPE). This group of bacteria causes a broad range of infections in humans and has become a major public health concern due to its ability to resist the last-line class of antibiotics, carbapenems.
Previously I was a PhD student in the Pathogen Genomics group at the Sanger Institute. My PhD research used genomic data to study the evolution and population dynamics of the bacterial pathogen, Legionella pneumophila, the causative agent of Legionnaires' disease.
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread.
Nature microbiology 2019;4;11;1919-1929
Spatial structuring of a Legionella pneumophila population within the water system of a large occupational building.
Microbial genomics 2018;4;10
Low genomic diversity of Legionella pneumophila within clinical specimens.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018;24;9;1020.e1-1020.e4
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.
PLoS genetics 2017;13;6;e1006855
Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires' Disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017;64;9;1251-1259
Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2017;23;4;264.e1-264.e9
Genomic investigation of a suspected outbreak of Legionella pneumophila ST82 reveals undetected heterogeneity by the present gold-standard methods, Denmark, July to November 2014.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2017;22;25
Evaluation of an Optimal Epidemiological Typing Scheme for Legionella pneumophila with Whole-Genome Sequence Data Using Validation Guidelines.
Journal of clinical microbiology 2016;54;8;2135-48
Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently.
Genome research 2016;26;11;1555-1564
A bit of a mouthful.
Nature reviews. Microbiology 2016;14;9;548
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.
Scientific reports 2016;6;20954
Transmission Clusters of Methicillin-Resistant Staphylococcus Aureus in Long-Term Care Facilities Based on Whole-Genome Sequencing.
Infection control and hospital epidemiology 2016;37;6;685-91
Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom.
It's diversity all the way down.
Nature reviews. Microbiology 2015;13;12;740