Dr Peter Clapham | ISG Team Leader

Clapham, Peter

Peter leads the Informatics Support Group (ISG) which provides the high performance compute (HPC) environments for Sangers scientific research teams. Our team investigates new and upcoming technical solutions that will drive our HPC platforms for tomorrow. In this way we can continue to keep abreast of the research challenges presented.

Traditional high performance computing has become a reliable and performant environment that has permitted Sanger's research teams to remain at the forefront of scientific endeavour over the past 20 years. As sequencing technologies continue to develop and mature, the opportunities that are presented to our research groups has grown beyond the abilities of these systems to scale appropriately. Today our group is developing highly flexible compute platforms based upon OpenStack and the very latest in software defined 100Gb/s native networking. By exploiting these systems we will be able to address the dynamic challenges presented in an increasingly timely, adaptable and cost effective manner.

As a group we continue to develop and manage our 18Pb of storage under an iRODS platform. This is a project that our group started in 2009 and is Sanger's repository for all locally generated sequence data from that time.

IT as a field is bringing new and disruptive technologies to the market. Our team is in an excellent position to engage with external companies and accademic sites to ensure that Sanger's IT remains at the forefront of IT technology, infrastructure and flexible and adaptive high performance computing.

Publications

  • Implementing a genomic data management system using iRODS in the Wellcome Trust Sanger Institute.

    Chiang GT, Clapham P, Qi G, Sale K and Coates G

    BMC bioinformatics 2011;12;361

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Ensembl 2016.

    Yates A, Akanni W, Amode MR, Barrell D, Billis K et al.

    Nucleic acids research 2016;44;D1;D710-6

  • Ensembl 2015.

    Cunningham F, Amode MR, Barrell D, Beal K, Billis K et al.

    Nucleic acids research 2015;43;Database issue;D662-9

  • Ensembl 2014.

    Flicek P, Amode MR, Barrell D, Beal K, Billis K et al.

    Nucleic acids research 2014;42;Database issue;D749-55

  • Cytotoxicity and genotoxicity of diallyl sulfide and diallyl disulfide towards Chinese hamster ovary cells.

    Musk SR, Clapham P and Johnson IT

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35;3-4;379-85

  • Bystander-mediated genomic instability after high LET radiation in murine primary haemopoietic stem cells.

    Bowler DA, Moore SR, Macdonald DA, Smyth SH, Clapham P and Kadhim MA

    Mutation research 2006;597;1-2;50-61

  • Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particles.

    Hill MA, Ford JR, Clapham P, Marsden SJ, Stevens DL et al.

    Radiation research 2005;163;1;36-44

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Ensembl 2015.

    Cunningham F, Amode MR, Barrell D, Beal K, Billis K et al.

    Nucleic acids research 2015;43;Database issue;D662-9

  • Ensembl 2014.

    Flicek P, Amode MR, Barrell D, Beal K, Billis K et al.

    Nucleic acids research 2014;42;Database issue;D749-55

  • Implementing a genomic data management system using iRODS in the Wellcome Trust Sanger Institute.

    Chiang GT, Clapham P, Qi G, Sale K and Coates G

    BMC bioinformatics 2011;12;361

Clapham, Peter
Peter's Timeline
2015

Informatics Support Group Leader with the Wellcome Trust Sanger Institute.

2005

Principle Systems Administrator at the Wellcome Trust Sanger Institute.

2001

Departmental Unix and HPC Computer Officer for the Chemistry Department at the University of Cambridge

1997

Postdoctoral Research Position with the MRC Harwell Radiation Induced Genomic Instability Unit.

1994

PhD studies into radiosensitivity with The University of Bristol, completed 1998.