Sofia Chen | PhD Student

Chen, Sofia

My research focuses on melanoma genetics and immuno-oncology. My first project involves profiling the genetic landscape of a large number of human primary melanoma tumours, identifying novel driver genes and interactions. My second project uses genome-wide CRISPR-Cas9 screening to understand how tumour PD-L1 expression can be downregulated to reverse immune cell exhaustion and facilitate tumour cell killing.

Publications

  • ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

    Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I et al.

    Nature communications 2019;10;1;2213

  • Intrinsic Clearance Assay Incubational Binding: A Method Comparison.

    Chen S, Prieto Garcia L, Bergström F, Nordell P and Grime K

    Drug metabolism and disposition: the biological fate of chemicals 2017;45;4;342-345

  • ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

    Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I et al.

    Nature communications 2019;10;1;2213

  • Intrinsic Clearance Assay Incubational Binding: A Method Comparison.

    Chen S, Prieto Garcia L, Bergström F, Nordell P and Grime K

    Drug metabolism and disposition: the biological fate of chemicals 2017;45;4;342-345

Chen, Sofia
Sofia's Timeline
2016

Started PhD at the University of Cambridge

2015

Finished the Innovative Medicines and Early Development (iMed) Graduate Programme at AstraZeneca

2013

Master of Science in Biotechnology Engineering, Lund University, Sweden