I work with large patient cohorts, integrating genomic, transcriptomic and clinical data to investigate inter-individual variation in the host immune response. I’m particularly interested in understanding how the genetic background of a patient can impact their disease progression and response to treatment.
I obtained my PhD in Clinical Medicine at the Wellcome Centre for Human Genetics in Oxford, in Professor Julian Knight’s lab. My research focused on applying functional genomics methods to explore the host sepsis response as part of the Genomic Advances in Sepsis (GAinS) study. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, and is a major cause of death both in the UK and worldwide. I used complementary -omics data sets (genotyping, transcriptomics, proteomics) to explore disease subgroups or endotypes revealed by host transcriptomics that could present an opportunity for a precision medicine approach to sepsis management. Most recently, we identified a differential response to treatment across endotypes in the VANISH clinical trial.