Dr Katie Burnham | Postdoctoral Fellow

Burnham, Katie

Katie is a Postdoctoral Fellow in Dr Emma Davenport’s team. Her work investigates variation in the host immune response and its potential relevance in clinical decision making and drug development.

I work with large patient cohorts, integrating genomic, transcriptomic and clinical data to investigate inter-individual variation in the host immune response. I’m particularly interested in understanding how the genetic background of a patient can impact their disease progression and response to treatment.

I obtained my PhD in Clinical Medicine at the Wellcome Centre for Human Genetics in Oxford, in Professor Julian Knight’s lab. My research focused on applying functional genomics methods to explore the host sepsis response as part of the Genomic Advances in Sepsis (GAinS) study. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, and is a major cause of death both in the UK and worldwide. I used complementary -omics data sets (genotyping, transcriptomics, proteomics) to explore disease subgroups or endotypes revealed by host transcriptomics that could present an opportunity for a precision medicine approach to sepsis management. Most recently, we identified a differential response to treatment across endotypes in the VANISH clinical trial.

Publications

  • Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.

    Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ et al.

    American journal of respiratory and critical care medicine 2019;199;8;980-986

  • Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

    Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE et al.

    The Lancet. Respiratory medicine 2017;5;10;816-826

  • Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

    Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC et al.

    American journal of respiratory and critical care medicine 2017;196;3;328-339

  • Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

    Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P et al.

    The Lancet. Respiratory medicine 2016;4;4;259-71

  • A genetics-led approach defines the drug target landscape of 30 immune-related traits.

    Fang H, ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL et al.

    Nature genetics 2019;51;7;1082-1091

  • Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.

    Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ et al.

    American journal of respiratory and critical care medicine 2019;199;8;980-986

  • A community approach to mortality prediction in sepsis via gene expression analysis.

    Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA et al.

    Nature communications 2018;9;1;694

  • Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

    Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE et al.

    The Lancet. Respiratory medicine 2017;5;10;816-826

  • Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

    Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC et al.

    American journal of respiratory and critical care medicine 2017;196;3;328-339

  • XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.

    Fang H, Knezevic B, Burnham KL and Knight JC

    Genome medicine 2016;8;1;129

  • Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

    Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P et al.

    The Lancet. Respiratory medicine 2016;4;4;259-71

Burnham, Katie
Katie's Timeline
2019

Joined WSI as a Postdoctoral Fellow

2017

Started as a Postdoctoral Research Fellow, Knight group, University of Oxford

2013

Began DPhil in Clinical Medicine, Knight group, University of Oxford

2012

Masters in Genetics, Université Denis Diderot, Paris