Mathew Beale | Postdoctoral Fellow

Beale, Mathew

I am a molecular and computational biologist, specialising in the genomic epidemiology and evolution of pathogens. I have expertise in genomic laboratory methods and bioinformatic analysis of pathogen genomes, and work with viral, fungal and bacterial human pathogens. I try to synergise approaches from different fields, e.g. applying well established tools and techniques from eukaryotic genomics to the study of pathogen genomes, or using viral approaches to within-host evolution for studying bacteria; this uses a combination of established tools and de novo scripted analyses methods.

My current research in the Thomson group at WSI focuses on Sexually Transmitted (STIs) and Neglected Diseases (NTDs), with a particular focus on the Treponemas, causative agents of Syphilis and Yaws. I use genome sequencing and population genomics to address questions of inter- and intra-host evolutionary dynamics and population structure, host adaptation and acquisition of virulence, and patient-to-patient transmission.


  • Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

    Beale MA, Sabiiti W, Robertson EJ, Fuentes-Cabrejo KM, O'Hanlon SJ et al.

    PLoS neglected tropical diseases 2015;9;6;e0003847

  • Clinical and biological insights from viral genome sequencing.

    Houldcroft CJ, Beale MA and Breuer J

    Nature reviews. Microbiology 2017;15;3;183-192

  • Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV/AIDS cohort.

    Vanhove M, Beale MA, Rhodes J, Chanda D, Lakhi S et al.

    Molecular ecology 2017;26;7;1991-2005

  • A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.

    Rhodes J, Beale MA, Vanhove M, Jarvis JN, Kannambath S et al.

    G3 (Bethesda, Md.) 2017;7;4;1165-1176

  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

    Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M et al.

    Genetics 2017;207;1;327-346

Beale, Mathew
Mathew's Timeline

Postdoctoral Fellow in Bacterial Genomics at Sanger Institute


Research Associate in Viral Genomics at University College London


Postdoctoral Research Associate in Fungal Genomics jointly between St George's University London and Imperial College


PhD Student in Virology at Public Health England and University College London

Research Assistant in Virology at Public Health England


Biomedical Scientist in Transfusion Science (inc. Transfusion Virology) at NHSBT