Dr Mathew Beale | Postdoctoral Fellow

Beale, Mathew

I am a molecular and computational microbiologist, with broad wet and dry lab experience, expertise in genomic laboratory methods and bioinformatic analysis of pathogen genomes, working with viral, fungal and bacterial human pathogens. My research focuses on the use of genome sequencing and population genomics to address questions of inter- and intra-host evolutionary and transmission dynamics, population structure, host adaptation and acquisition of virulence.

In my current research in the Thomson group at WSI, I have continued previous work on direct sequencing approaches for pathogen genomics, developing laboratory and computational approaches for difficult to sequence (primarily bacterial) pathogens, and this has included substantial metagenomics. My primary research focuses on bacterial sexually transmitted infections (STIs) and neglected tropical diseases (NTDs), with a current emphasis on Treponema species (e.g. Syphilis, Yaws), where I am addressing questions around global genomic diversity, evolutionary drivers and history, and disease transmission epidemiology.

Publications

  • Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages.

    Beale MA, Marks M, Sahi SK, Tantalo LC, Nori AV et al.

    Nature communications 2019;10;1;3255

  • Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

    Beale MA, Sabiiti W, Robertson EJ, Fuentes-Cabrejo KM, O'Hanlon SJ et al.

    PLoS neglected tropical diseases 2015;9;6;e0003847

  • Clinical and biological insights from viral genome sequencing.

    Houldcroft CJ, Beale MA and Breuer J

    Nature reviews. Microbiology 2017;15;3;183-192

  • Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV/AIDS cohort.

    Vanhove M, Beale MA, Rhodes J, Chanda D, Lakhi S et al.

    Molecular ecology 2017;26;7;1991-2005

  • A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.

    Rhodes J, Beale MA, Vanhove M, Jarvis JN, Kannambath S et al.

    G3 (Bethesda, Md.) 2017;7;4;1165-1176

  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

    Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M et al.

    Genetics 2017;207;1;327-346

  • Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages.

    Beale MA, Marks M, Sahi SK, Tantalo LC, Nori AV et al.

    Nature communications 2019;10;1;3255

  • Identification of novel adenovirus genotype 90 in children from Bangladesh.

    Houldcroft CJ, Beale MA, Sayeed MA, Qadri F, Dougan G and Mutreja A

    Microbial genomics 2018

  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

    Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M et al.

    Genetics 2017;207;1;327-346

  • On the effective depth of viral sequence data.

    Illingworth CJR, Roy S, Beale MA, Tutill H, Williams R and Breuer J

    Virus evolution 2017;3;2;vex030

  • A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.

    Rhodes J, Beale MA, Vanhove M, Jarvis JN, Kannambath S et al.

    G3 (Bethesda, Md.) 2017;7;4;1165-1176

  • Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV/AIDS cohort.

    Vanhove M, Beale MA, Rhodes J, Chanda D, Lakhi S et al.

    Molecular ecology 2017;26;7;1991-2005

  • Clinical and biological insights from viral genome sequencing.

    Houldcroft CJ, Beale MA and Breuer J

    Nature reviews. Microbiology 2017;15;3;183-192

  • Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

    Beale MA, Sabiiti W, Robertson EJ, Fuentes-Cabrejo KM, O'Hanlon SJ et al.

    PLoS neglected tropical diseases 2015;9;6;e0003847

Beale, Mathew
Mathew's Timeline
2017

Postdoctoral Fellow in Bacterial Genomics at Sanger Institute

2015

Research Associate in Viral Genomics at University College London

2012

Postdoctoral Research Associate in Fungal Genomics jointly between St George's University London and Imperial College

2008

PhD Student in Virology at Public Health England and University College London

Research Assistant in Virology at Public Health England

2002

Biomedical Scientist in Transfusion Science (inc. Transfusion Virology) at NHSBT